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Discovering the causes of cancer and the means of prevention

Hormonal and Reproductive Epidemiology Branch

Understanding mechanisms to prevent hormonally-related cancers

The Hormonal and Reproductive Epidemiology Branch (HREB) conducts research to identify groups at high risk of cancer, clarify the natural history of various cancers, understand the interactive effects of genetic and environmental factors on cancer risk, and elucidate biologic mechanisms of carcinogenesis.

Research Mission

HREB's research mission is to focus on hormonal and reproductive cancers, and other malignancies with possible hormonal etiologies (e.g., liver, esophageal). Learn about specific HREB research areas.


HREB fellows enjoy unique opportunities to collaborate and learn from investigators in a world-renowned research program. Fellows have access to large population-based studies with biological specimens and are encouraged to initiate new investigations and to compete for funding. Meet the current HREB fellows and learn about research training opportunities in HREB.

Distinguished Lecture Series

HREB launched the Distinguished Lecture Series in 2004. Each year, a prominent scientist is invited to visit for two days to give a lecture and meet with DCEG staff to discuss issues relevant to research on causes of hormonal and reproductive cancers. The objectives of this series are to expand and intensify contacts between intramural and extramural investigators, provide an opportunity for junior staff to meet with distinguished scientists, and stimulate new opportunities for research in the area of hormonal and reproductive cancers. Read more about the HREB Distinguished Lecture Series.

Staff Spotlights

Britton Trabert

Dr. Britton Trabert was selected as a 2014 NIH Earl Stadtman Investigator. Read more about Dr. Trabert's appointment.

HREB Highlights

Brinton LA, Key TJ, et al. Prediagnostic sex steroid hormones in relation to male breast cancer risk. J Clin Oncol 2015; May 11 (E-pub).

McGlynn KA, Hagberg K, et al. Statin use and risk of primary liver cancer in the Clinical Practice Research Datalink. J Natl Cancer Inst 2015;107:djv009.

Nyante SJ, Sherman ME, et al. Prognostic significance of mammographic density change after initiation of tamoxifen for ER-positive breast cancer. J Natl Cancer Inst 2015;107;dju425.

Wentzensen N, Walker JL, et al. Multiple biopsies and detection of cervical cancer precursors at colposcopy. J Clin Oncol 2015;33:83-9.