Biography

Dr. Abnet received a Ph.D. in Environmental Toxicology from the University of Wisconsin in 1998 and an M.P.H. in Epidemiology from the University of Minnesota in 1999. He joined NCI as a Cancer Prevention Fellow in the Division of Cancer Prevention in 1998 and became an investigator in the Nutritional Epidemiology Branch in 2005.

Research Interests

• Etiologic studies of esophageal and gastric cancer
• Developing exposure markers for nutritional and toxic elements for use in epidemiologic studies
• Oral health and cancer
• Early detection methods for esophageal squamous cell carcinoma in high-risk populations
• Member of the DCEG Upper Gastrointestinal Cancers Research Group

Keywords

esophageal squamous cell carcinoma, esophageal adenocarcinoma, gastric adenocarcinoma, element status, oral health, early detection

Selected Publications

• Abnet CC, Freedman ND, Hu N, Wang Z, Yu K, Shu XO, Yuan JM, Zheng W, Dawsey SM, Dong LM, Lee MP, Ding T, Qiao YL, Gao YT, Koh WP, Xiang YB, Tang ZZ, Fan JH, Wang C, Wheeler W, Gail MH, Yeager M, Yuenger J, Hutchinson A, Jacobs KB, Giffen CA, Burdett L, Fraumeni JF Jr, Tucker MA, Chow WH, Goldstein AM, Chanock SJ, Taylor PR. A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. Nat Genet 2010 Sep;42(9):764-7.
• Dawsey SP, Tonui S, Parker RK, Fitzwater JW, Dawsey SM, White RE, Abnet CC. Esophageal cancer in young people: a case series of 109 cases and review of the literature. PLoS One 2010 Nov 22;5(11):e14080.
• Murphy G, Fan JH, Mark SD, Dawsey SM, Selhub J, Wang J, Taylor PR, Qiao YL, Abnet CC. Prospective study of serum cysteine levels and oesophageal and gastric cancers in China. Gut 2011 Jan 27.
• Cardwell CR, Abnet CC, Cantwell MM, Murray LJ. Exposure to oral bisphosphonates and risk of esophageal cancer. JAMA 2010 Aug 11;304(6):657-63.
• Abnet CC, Chen Y, Chow WH, Gao YT, Helzlsouer KJ, Le Marchand L, McCullough ML, Shikany JM, Virtamo J, Weinstein SJ, Xiang YB, Yu K, Zheng W, Albanes D, Arslan AA, Campbell DS, Campbell PT, Hayes RB, Horst RL, Kolonel LN, Nomura AM, Purdue MP, Snyder K, Shu XO. Circulating 25-hydroxyvitamin D and risk of esophageal and gastric cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol 2010 Jul 1;172(1):94-106.
• Abnet CC, Kamangar F, Islami F, Nasrollahzadeh D, Brennan P, Aghcheli K, Merat S, Pourshams A, Marjani HA, Ebadati A, Sotoudeh M, Boffetta P, Malekzadeh R, Dawsey SM. Tooth loss and lack of regular oral hygiene are associated with higher risk of esophageal squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 2008 Nov;17(11):3062-8.

Collaborators

DCEG Collaborators

• Neal Freedman, Ph.D., M.P.H.; Sanford Dawsey, M.D.; Philip Taylor, M.D., Sc.D.; Arthur Schatzkin, M.D., Dr.P.H.; Wong-Ho Chow, Ph.D.; Michael Cook, Ph.D.; Katherine McGlynn, Ph.D.; Demetrius Albanes, M.D.

Other Scientific Collaborators

• Paulo Boffetta, M.D., IARC, Lyon, France
• Paul Brennan, Ph.D., IARC, Lyon, France
• Zhi-Wei Dong, M.D., Cancer Institute, Chinese Academy of Medical Sciences
• Bruce Dye, Centers for Disease Control and Prevention, National Center for Health Statistics, Hyattsville, Maryland, USA
• Renato Fagundes, M.D., Universidade Federal de Santa Maria, Santa Maria, Brazil
• Farin Kamangar, M.D., Ph.D., Morgan State University, Baltimore, MD
• Paul Limburg, M.D., M.P.H., Mayo Clinic, Rochester, MN, USA
• Reza Malekzadeh, M.D., DDRC, Tehran University, Iran
• Steven Mark, M.D., Sc.D., University of Colorado, Boulder, CO, USA
• Liam Murray, Queen’s University, Belfast, Northern Ireland, UK
• You-Lin Qiao, M.D., Ph.D., Cancer Institute, Chinese Academy of Medical Sciences
• Mark Roth, M.D.; Clinical Center, National Cancer Institute
• Vikash Sewram, Ph.D., PROMEC, Medical Research Council, South Africa
• Paul Strickland, Ph.D., The Johns Hopkins University, Baltimore, MD, USA
• Wen-Qiang Wei, M.D., Cancer Institute, Chinese Academy of Medical Sciences
• Russ White, M.D., Tenwek Hospital, Bomet, Kenya