Biography

Born in France, Dr. Bouville obtained his Ph.D. in Physics at the University Paul-Sabatier in Toulouse in 1970. He was Scientific Secretary of the United Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) from 1970 to 1972 and remained associated with that Committee as a consultant until 2000. From 1972 to 1984, Dr. Bouville was employed in France by the Institute of Protection and Nuclear Safety, where he contributed to a number of environmental and dosimetric studies related to nuclear facilities. He joined the National Cancer Institute in 1984, where, first as an Expert and then as a Senior Radiation Physicist, Dr. Bouville has been involved mainly in the estimation of radiation doses resulting from radioactive fallout from atmospheric nuclear weapons tests and from the Chornobyl accident. His current position is head of the Radiation Dosimetry Unit of the Radiation Epidemiology Branch.

Research Interests

Dr. Bouville is involved to a varying extent in all of the dosimetry activities in the Radiation Epidemiology Branch, which can be classified into five major categories:

• Individual dose assessment of subjects enrolled in three Chornobyl-related epidemiologic studies: two related studies of thyroid disease among children (one in Belarus and the other in Ukraine), and one study of leukemia among Ukrainian clean-up workers.
• Individual dose assessment for study subjects in an epidemiologic study of thyroid cancer and nodules in relation to radioactive fallout from atmospheric nuclear weapons tests at the Semipalatinsk Test Site in Kazakhstan.
• Studies related to the estimation of doses received by the U.S. population as a consequence of nuclear weapons testing in the U.S. and elsewhere in the world.
• Other Branch research projects: a large cohort study of U.S. radiologic technologists who worked from the early 1920s until 1984, a study of hyperthyroidism among patients treated with 131I, and other epidemiologic studies conducted in the Branch related to medical exposures.
• Service including mentoring, collaborations, participation as a committee member or expert in national and international organizations, and providing information and advice to professional and non-professional groups and individuals.

Keywords

Chornobyl, fallout, dose, Iodine-131

Selected Publications

• Hatch M, Ron E, Bouville A, Zablotska L, Howe G. The Chernobyl disaster: cancer following the accident at the Chernobyl nuclear power plant. Epidemiol Rev 2005;27:56-66. Review.
• Simon SL, Bouville A, Land CE. Fallout from nuclear weapons tests and cancer risks. American Scientist 2006;94:48-57.
• Balonov M, Alexakhin R, Bouville A, Liljinzin JO. Report from the techa river dosimetry review workshop held on 8-10 December 2003 at The State Research Centre Institute of Biophysics, Moscow, Russia. Health Phys 2006 Feb;90(2):97-113.
• Minenko VF, Ulanovsky AV, Drozdovitch VV, Shemiakina EV, Gavrilin YI, Khrouch VT, Shinkarev SM, Voillequé PG, Bouville A, Anspaugh LR, Luckyanov N. Individual thyroid dose estimates for a case-control study of chernobyl-related thyroid cancer among children of Belarus--part II. Contributions from long-lived radionuclides and external radiation. Health Phys 2006 Apr;90(4):312-27.
• Drozdovitch V, Germenchuk M, Bouville A. Using total beta-activity measurements in milk to derive thyroid doses from Chernobyl fallout. Radiat Prot Dosimetry 2006;118(4):402-11.
• Bouville A, Chumak VV, Inskip PD, Kryuchkov V, Luckyanov N. The chornobyl accident: estimation of radiation doses received by the Baltic and Ukrainian cleanup workers. Radiat Res 2006 Jul;166(1 Pt 2):158-67.
• Likhtarev I, Bouville A, Kovgan L, Luckyanov N, Voillequé P, Chepurny M. Questionnaire- and measurement-based individual thyroid doses in Ukraine resulting from the Chornobyl nuclear reactor accident. Radiat Res 2006 Jul;166(1 Pt 2):271-86.
• Beck HL, Anspaugh LR, Bouville A, Simon SL. Review of methods of dose estimation for epidemiological studies of the radiological impact of nevada test site and global fallout. Radiat Res 2006 Jul;166(1 Pt 2):209-18. Review.
• Simon SL, Weinstock RM, Doody MM, Neton J, Wenzl T, Stewart P, Mohan AK, Yoder RC, Hauptmann M, Freedman DM, Cardarelli J, Feng HA, Bouville A, Linet M. Estimating historical radiation doses to a cohort of U.S. radiologic technologists. Radiat Res 2006 Jul;166(1 Pt 2):174-92.
• Tronko MD, Howe GR, Bogdanova TI, Bouville AC, Epstein OV, Brill AB, Likhtarev IA, Fink DJ, Markov VV, Greenebaum E, Olijnyk VA, Masnyk IJ, Shpak VM, McConnell RJ, Tereshchenko VP, Robbins J, Zvinchuk OV, Zablotska LB, Hatch M, Luckyanov NK, Ron E, Thomas TL, Voillequé PG, Beebe GW. A cohort study of thyroid cancer and other thyroid diseases after the chornobyl accident: thyroid cancer in Ukraine detected during first screening. J Natl Cancer Inst 2006 Jul 5;98(13):897-903.
• Brill AB, Stabin M, Bouville A, Ron E. Normal organ radiation dosimetry and associated uncertainties in nuclear medicine, with emphasis on iodine-131. Radiat Res 2006 Jul;166(1 Pt 2):128-40.
• Simon SL, Bouville A, Kleinerman R, Ron E. Dosimetry for epidemiological studies: learning from the past, looking to the future. Radiat Res 2006 Jul;166(1 Pt 2):313-8.
• Simon SL, Kleinerman RA, Ron E, Bouville A. Uses of dosimetry in radiation epidemiology. Radiat Res 2006 Jul;166(1 Pt 2):125-7.
• Likhtarov I, Kovgan L, Vavilov S, Chepurny M, Ron E, Lubin J, Bouville A, Tronko N, Bogdanova T, Gulak L, Zablotska L, Howe G. Post-Chernobyl thyroid cancers in Ukraine. Report 2: risk analysis. Radiat Res 2006 Aug;166(2):375-86.
• Sholom S, Chumak V, Desrosiers M, Bouville A. A transferability study of the EPR-tooth-dosimetry technique. Radiat Prot Dosimetry 2006;120(1-4):210-5.
• Drozdovitch V, Bouville A, Chobanova N, Filistovic V, Ilus T, Kovacic M, Malátová I, Moser M, Nedveckaite T, Völkle H, Cardis E. Radiation exposure to the population of Europe following the Chernobyl accident. Radiat Prot Dosimetry 2007;123(4):515-28.
• Simon SL, Bailiff I, Bouville A, Fattibene P, Kleinerman RA, Lloyd DC, McKeever SWS, Romanyukha A, Sevan'kaev AV, Tucker JD, Wieser A. BiodosEPR-2006 Consensus Committee Report on Biodosimetric Methods to Evaluate Radiation Doses at Long Times After Exposure. Radiation Measurements 2007;42:948-71.
• Sholom S, Desrosiers M, Bouville A, Luckyanov N, Chumak V, Simon SL. EPR Tooth Dosimetry of Semipalatinsk Nuclear Test Site Area Inhabitants. Radiation Measurements 2007;42:1037-40.
• Bouville A, Likhtarev IA, Kovgan LN, Minenko VF, Shinkarev SM, Drozdovitch VV. Radiation dosimetry for highly contaminated Belarusian, Russian and Ukrainian populations, and for less contaminated populations in Europe. Health Phys 2007 Nov;93(5):487-501. Review.
• Drozdovitch V, Maceika E, Khrouch V, Zvonova I, Vlasov O, Bouville A, Cardis E. Uncertainties in individual doses in a case-control study of thyroid cancer after the Chernobyl accident. Radiat Prot Dosimetry 2007;127(1-4):540-3.
• Balonov MI, Anspaugh LR, Bouville A, Likhtarev IA. Contribution of internal exposures to the radiological consequences of the Chernobyl accident. Radiat Prot Dosimetry 2007;127(1-4):491-6.
• Shinkarev SM, Voillequé PG, Gavrilin YI, Khrouch VT, Bouville A, Hoshi M, Meckbach R, Minenko VF, Ulanovsky AV, Luckyanov N. Credibility of Chernobyl thyroid doses exceeding 10 Gy based on in-vivo measurements of 131I in Belarus. Health Phys 2008 Feb;94(2):180-7.
• Land CE, Zhumadilov Z, Gusev BI, Hartshorne MH, Wiest PW, Woodward PW, Crooks LA, Luckyanov NK, Fillmore CM, Carr Z, Abisheva G, Beck HL, Bouville A, Langer J, Weinstock R, Gordeev KI, Shinkarev S, Simon SL. Ultrasound-detected thyroid nodule prevalence and radiation dose from fallout. Radiat Res 2008 Apr;169(4):373-83.
• Drozdovitch V, Bouville A, Doyon F, Brindel P, Cardis E, de Vathaire F. Reconstruction of individual radiation doses for a case-control study of thyroid cancer in French Polynesia. Health Phys 2008 May;94(5):418-33.
• Romanenko A, Bebeshko V, Hatch M, Bazyka D, Finch S, Dyagil I, Reiss R, Chumak V, Bouville A, Gudzenko N, Zablotska L, Pilinskaya M, Lyubarets T, Bakhanova E, Babkina N, Trotsiuk N, Ledoschuk B, Belayev Y, Dybsky SS, Ron E, Howe G. The Ukrainian-American study of leukemia and related disorders among Chornobyl cleanup workers from Ukraine: I. Study methods. Radiat Res 2008 Dec;170(6):691-7.
• Chumak VV, Romanenko AY, Voillequé PG, Bakhanova EV, Gudzenko N, Hatch M, Zablotska LB, Golovanov IA, Luckyanov NK, Sholom SV, Kryuchkov VP, Bouville A. The Ukrainian-American study of leukemia and related disorders among Chornobyl cleanup workers from Ukraine: II. Estimation of bone marrow doses. Radiat Res 2008 Dec;170(6):698-710.
• Romanenko AY, Finch SC, Hatch M, Lubin JH, Bebeshko VG, Bazyka DA, Gudzenko N, Dyagil IS, Reiss RF, Bouville A, Chumak VV, Trotsiuk NK, Babkina NG, Belyayev Y, Masnyk I, Ron E, Howe GR, Zablotska LB. The Ukrainian-American study of leukemia and related disorders among Chornobyl cleanup workers from Ukraine: III. Radiation risks. Radiat Res 2008 Dec;170(6):711-20.
• Kesminiene A, Evrard AS, Ivanov VK, Malakhova IV, Kurtinaitis J, Stengrevics A, Tekkel M, Anspaugh LR, Bouville A, Chekin S, Chumak VV, Drozdovitch V, Gapanovich V, Golovanov I, Hubert P, Illichev SV, Khait SE, Kryuchkov VP, Maceika E, Maksyoutov M, Mirkhaidarov AK, Polyakov S, Shchukina N, Tenet V, Tserakhovich TI, Tsykalo A, Tukov AR, Cardis E. Risk of hematological malignancies among Chernobyl liquidators. Radiat Res 2008 Dec;170(6):721-35.
• Khrutchinsky A, Kutsen S, Minenko V, Zhukova O, Luckyanov N, Bouville A, Drozdovitch V. Monte Carlo modeling of beta-radiometer device used to measure milk contaminated as a result of the Chernobyl accident. Appl Radiat Isot 2009 Jun;67(6):1089-93.
• Hatch M, Brenner A, Bogdanova T, Derevyanko A, Kuptsova N, Likhtarev I, Bouville A, Tereshchenko V, Kovgan L, Shpak V, Ostroumova E, Greenebaum E, Zablotska L, Ron E, Tronko M. A screening study of thyroid cancer and other thyroid diseases among individuals exposed in utero to iodine-131 from Chernobyl fallout. J Clin Endocrinol Metab 2009 Mar;94(3):899-906.