Biography

Dr. Dawsey received his M.D. degree from Stanford Medical School in 1976, completed his residency in pathology at the University of Colorado in 1981, and completed a fellowship in cytology at the University of California, Los Angeles, in 1987. He served as a staff pathologist at the McCormick Hospital in Chiang Mai, Thailand from 1982 to 1984 and at Saint Joseph Hospital in Denver, Colorado from 1984 to 1986. He joined NCI in 1987 and received tenure in 1995. He joined the Nutritional Epidemiology Branch of DCEG in 2005.

Research Interests

• Prevention and control of esophageal and gastric cancers
• Etiologic studies of esophageal and gastric cancers, especially in high-risk populations
• Developing clinically useful techniques for the early detection and treatment of esophageal and gastric cancers
• Member of the DCEG Upper Gastrointestinal Cancers Research Group

Keywords

Esophageal cancer, gastric cancer, early cancer detection, endoscopic thereapy, chemoprevention

Selected Publications

• Qiao YL, Dawsey SM, Kamangar F, Fan, JH, Abnet CC, Sun XD, Johnson LL, Dong ZW, Yu B, Mark SD, Taylor PR. Total and cancer mortality following supplementation with vitamins and minerals: Post-intervention follow-up of the General Population Nutrition Intervention Trial in Linxian China. J Natl Cancer Inst, in press.
• Limburg PL, Wei WQ, Ahnen DJ, Qiao YL, Hawk ET, Wang GQ, Giffen CA, Wang GQ, Roth MJ, Lu N, Korn EL, Ma YR, Gunter EW, Dong ZW, Taylor PR, Dawsey SM. Randomized, placebo-controlled, esophageal squamous cell cancer chemoprevention trial of selenomethionine and celecoxib. Gastroenterology 2005; 129:863-73.
• Murphy G, Fan JH, Mark SD, Dawsey SM, Selhub J, Taylor PR, Qiao YL, Abnet CC. Prospective study of serum cysteine levels and esophageal and gastric cancers in China.Gut 2011 Jan;27.[Epub ahead of print].
• Kamangar F, Qiao YL, Schiller JT, Dawsey SM, Fears T, Sun XD, Abnet CC, Zhao P, Taylor PR, Mark SD. Human papillomavirus serology and the risk of esophageal and gastric cancers: results from a cohort in a high-risk region of China. Int J Cancer 2006; 119:579-84.
• Koshiol J, Wei W, Kreimer AR, Chen W, Gravitt P, Ren JS, Abnet CC, Wang JB, Kamangar F, Lin DM, von Knebel Doeberitz M, Zhang Y, Viscidi R, Wang GQ, Gillison ML, Roth MJ, Dong ZW, Kim E, Taylor PR, Qiao YL, Dawsey SM. No role for human papillomavirus in esophageal squamous cell carcinoma in China. Int J Cancer 2010; 127:93-100.
• Kamangar F, Dawsey SM, Blaser MJ, Perez-Perez GI, Pietinen P, Newschaffer CJ, Abnet CC, Albanes D, Virtamo J, Taylor PR. Opposing risks of gastric cardia and noncardia gastric adenocarcinomas associated with Helicobacter pylori seropositivity. J Natl Cancer Inst 2006 Oct 18;98(20):1445-52.
• Cook MB, Dawsey SM, Diaw L, Blaser MJ, Perez-Perez GI, Abnet CC, Taylor PR, Albanes D, Virtamo J, Kamangar F. Serum pepsinogens and Helicobacter pylori in relation to the risk of esophageal squamous cell carcinoma in the alpha-tocopherol, beta-carotene cancer prevention study. Cancer Epidemiol Biomarkers Prev 2010; 19:1966-752.
• Kamangar F, Qiao YL, Blaser MJ, Sun XD, Katki H, Fan JH, Perez-Perez GI, Abnet CC, Zhao P, Mark SD, Taylor PR, Dawsey SM. Helicobacter pylori and oesophageal and gastric cancers in a prospective study in China. Br J Cancer 2007 Jan 15;96(1):172-6.
• Dawsey SM, Shen Q, Nieberg RK, Liu SF, English SA, Cao J, Zhou B, Wang GQ, Lewin KJ, Liu FS, Roth MJ, Taylor PR. Studies of esophageal balloon cytology in Linxian, China. Cancer Epidemiol Biomarkers Prev 1997; 6:121-130.
• Pan QJ, Roth MJ, Guo HQ, Kochman ML, Wang GQ, Henry M, Wei WQ, Giffen CA, Lu N, Abnet CC, Hao CQ, Taylor PR, Qiao YL, Dawsey SM. Cytologic detection of esophageal squamous cell carcinoma and its precursor lesions using balloon samplers and liquid-based cytology in asymptomatic adults in Llinxian, China. Acta Cytol 2008 Jan-Feb;52(1):14-23. Erratum in: Acta Cytol. 2008 Mar-Apr;52(2):276.
• Wang GQ, Abnet CC, Shen Q, Lewin KJ, Sun XD, Roth MJ, Qiao YL, Mark SD, Dong ZW, Taylor PR, Dawsey SM. Histologic precursors of esophageal squamous cell carcinoma: results from a 13-year prospective follow-up study in a high-risk population. Gut 2005; 54:187-92.
• Dawsey SM, Fleischer DE, Wang GQ, Zhou B, Kidwell JA, Lu N, Lewin KJ, Roth MJ, Tio TL, Taylor PR. Mucosal iodine staining improves endoscopic visualization of squamous dysplasia and squamous cell carcinoma of the esophagus in Linxian, China. Cancer 1998; 83:220-31.
• Zhang YM, Bergman JJGHM, Weusten, Dawsey SM, Fleischer DE, Lu N, Wang GQ. Radiofrequency ablation for early esophageal squamous cell neoplasia. Endoscopy 2010; 42:327-33.
• Islami F, Kamangar F, Aghcheli K, Fahimi S, Semnani S, Taghavi N, Marjani HA, Merat S, Nassari-Moghaddam S, Pourshams A, Nouraie M, Khatibian M, Abedi B, Brazandeh MH, Ghaziani R, Sotoudeh M, Dawsey SM, Abnet CC, Taylor PR, Malekzadeh R. Epidemiologic features of upper gastrointestinal tract cancers in northeastern Iran. Br J Cancer 2004; 90:1402-6.
• Nasrollahzadeh D, Kamangar F, Aghcheli K, Sotoudeh M, Islami F, Abnet CC, Shakeri R, Pourshams A, Marjani HA, Nouraie M, Khatibian M, Semnani S, Ye W, Boffetta P, Dawsey SM, Malekzadeh R. Opium, tobacco, and alcohol use in relation to oesophageal squamous cell carcinoma in a high-risk area of Iran. Br J Cancer 2008 Jun 3;98(11):1857-63.
• Islami F, Pourshams A, Nasrollahzadeh D, Kamangar F, Fahimi S, Shakeri R, Abedi-Ardekani B, Merat S, Vahedi H, Semnani S, Abnet CC, Brennan P, Moller H, Saidi F, Dawsey SM, Malekzadeh R, Boffetta P. Tea drinking habits and esophageal cancer in a high risk area in northern Iran. Brit Med J, in press.
• Abedi-Ardekani B, Kamangar F, Hewitt SM, Hainaut P, Sotoudeh M, Abnet CC, Taylor PR, Boffetta P, Malekzadeh R, Dawsey SM. Polycyclic aromatic hydrocarbon exposure in esophageal tissue is strongly associated with risk of esophageal squamous cell carcinoma in northeastern Iran. Gut, 2010; 1178-83.
• Pourshams A, Khademi H, Malekshah AF, Islami F, Nouraei M, Sadjadi AR, Jaafari E, Rakhshani N, Salahi R, Semnani S, Kamangar F, Abnet CC, Dawsey SM, Boffetta P, Malekzadeh R. Cohort profile: the Golestan cohort study – a prospective study of esophageal cancer in northern Iran. Int J Epidemiol, in press.
• Parker RK, Dawsey SM, Abnet CC, White RE. Esophageal cancer in Bomet District, Western Kenya. Dis Esophagus, 2010; 23:128-35.
• Kamangar F, Schantz MM, Abnet CC, Fagundes RB, Dawsey SM. High levels of carcinogenic polycyclic aromatic hydrocarbons in mate drinks. Cancer Epidemiol Biomarkers Prev 2008 May;17(5):1262-8.

Collaborators

DCEG Collaborators

• Philip Taylor, M.D., Sc.D.; Christian Abnet, Ph.D., M.P.H.; Mark Roth, M.D.; Farin Kamangar, M.D., Ph.D.; Neal Freedman, Ph.D., M.P.H.; Jill Koshiol, Ph.D; Nan Hu, M.D., Ph.D.; Demetrius Albanes, M.D.; Rachael Stolzenberg-Solomon, Ph.D., M.P.H.; Wong-Ho Chow, Ph.D.; Mitchell Gail, M.D., Ph.D.; Alisa Goldstein, Ph.D; Michael Cook, Ph.D.

Other NCI Collaborators

• Edward Korn, Ph.D.; Armando Filie, M.D.; Mark Roth, M.D.

Other Scientific Collaborators

• Jiyoung Ahn, Ph.D., New York University, New York, NY, USA
• Jacques Bergman, M.D., Academisch Medisch Centrum, Amsterdam, The Netherlands
• Paulo Boffetta, M.D., IARC, Lyon, France
• Paul Brennan, Ph.D., IARC, Lyon, France
• Renato Fagundes, M.D., Universidade Federal de Santa Maria, Brazil
• David Fleischer, M.D., Mayo Clinic, Scottsdale, AZ, USA
• Pierre Hainaut, Ph.D., IARC, Lyon, France
• Laura Lee Johnson, Ph.D., NICAM, Bethesda, MD, USA
• Paul Limburg, M.D., M.P.H., Mayo Clinic, Rochester, MN, USA
• Reza Malekzadeh, M.D., DDRC, Tehran University, Iran
• Steven Mark, M.D., Sc.D., University of Colorado, Boulder, CO, USA
• You-Lin Qiao, M.D., Ph.D., Cancer Institute, Chinese Academy of Medical Sciences, P.R. China
• Vikash Sewram, Ph.D., PROMEC, Medical Research Council, South Africa
• Masoud Sotoudeh, M.D., Tehran University of Medical Sciences, Iran
• Paul Strickland, Ph.D., The Johns Hopkins University, Baltimore, MD, USA
• Mark Topazian, M.D., Mayo Clinic, Rochester, MN, USA
• Guiqi Wang, M.D., Cancer Institute, Chinese Academy of Medical Sciences, P.R. China
• Wen-Qiang Wei, M.D., Cancer Institute, Chinese Academy of Medical Sciences, P.R. China
• Russell White, M.D., Tenwek Hospital, Bomet, Kenya
• Weimin Ye, Ph.D., Karolinska Institute, Sweden