Biography
Dr. Goldin received a Ph.D. in genetics from the University of North Carolina at Chapel Hill in 1978. She was a researcher in the Clinical Neurogenetics Branch of the National Institute of Mental Health and joined the NCI Genetic Epidemiology Branch in 1998. Dr. Goldin's major research interests are in developing and evaluating statistical methods and study designs for detecting susceptibility genes for complex diseases, quantifying familial aggregation of disease, and applying these methods to familial cancer studies.
Research Interests
- Gene detection in families at high risk for lymphoproliferative tumors
- Statistical methods for genetic analyses
- Familial aggregation of hematologic malignancies and precursor conditions using Nordic registries
Keywords
linkage studies, association studies, gene mapping, candidate genes, familial aggregation, hematologic malignancies
Selected Publications
- Goldin LR, Landgren O. Autoimmunity and lymphomagenesis. Int J Cancer. 2008;[Epub ahead of print].
- Kristinsson SY, Bjorkholm M, Goldin LR, McMaster ML, Turesson I, Landgren O. Risk of lymphoproliferative disorders among first-degree relatives of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia patients: a population-based study in Sweden. Blood. 2008;112:3052-3056.
- Landgren O, Goldin LR, Kristinsson SY, Helgadottir EA, Samuelsson J, Bjorkholm M. Increased risks of polycythemia vera, essential thrombocythemia, and myelofibrosis among 24,577 first-degree relatives of 11,039 patients with myeloproliferative neoplasms in Sweden. Blood. 2008;112:2199-2204.
- Mellemkjaer L, Pfeiffer RM, Engels EA, Gridley G, Wheeler W, Hemminki K, Olsen JH, Dreyer L, Linet MS, Goldin LR, Landgren O. Autoimmune disease in individuals and close family members and susceptibility to non-Hodgkin’s lymphoma. Arthritis Rheum. 2008;58:657-666.
- Landgren O, Engels EA, Pfeiffer RM, Gridley G, Mellemkjaer L, Olsen JH, Kerstann KF, Wheeler W, Hemminki K, Linet MS, Goldin LR. Autoimmunity and susceptibility to Hodgkin lymphoma: a population-based case-control study in Scandinavia. Blood. 2007;109:916-925.
- Goldin LR, Slager SL. Familial CLL: Genes and environment. Hematology Am Soc Hematol Educ Program 2007;339-45.
- Sellick GS, Goldin LR, Wild RW, Slager SL, Rassenti L, Strom SS, Dyer MJS, Mauro FR, Marti FE, Fuller S, Lyttelton M, Kipps T, Keating MJ, Call TG, Catovsky D, Caporaso N, Houlston RS. A high-density SNP genome-wide linkage search of 206 families identifies susceptibility loci for chronic lymphocytic leukemia. Blood 2007;110:3326-3333.
- McMaster ML, Goldin LR, Bai Y, Ter-Minassian M, Boehringer S, Giambarresi TR, Vasquez LG, Tucker MA. Genome-wide linkage screen for Waldenström macroglobulinemia susceptibility loci in high-risk families. Am J Hum Genet 2006;79:695-701
- Landgren O, Engels EA, Pfeiffer RM, Gridley G, Mellemkjaer L, Olsen JH, Kerstann KF, Wheeler W, Hemminki K, Linet MS, Goldin LR. Autoimmunity and susceptibility to Hodgkin lymphoma: A population-based case-control study in Scandinavia. JNCI 2006;98(18:1321-30.
- Goldin LR, Pfeiffer RM, Li X, Hemminki K. Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: Results from the Swedish Family-Cancer Database. Blood 2004;104(6):1850-4.
