Biography

Dr. Loud received her B.S. in Nursing from Old Dominion University in 1981, followed by an M.S. in Nursing from George Mason University in 1992 and a Doctor of Nursing Practice from the University of Maryland, Baltimore in 2008. She has been a board-certified Adult Nurse Practitioner since 1992. She spent six years as a Nurse Practitioner with NCI's Medical Oncology Branch, working with individuals enrolled in clinical trials of new cancer treatments. During that time, she was a Clinical Trials Coordinator, and an Associate Investigator on two chemoprevention trials for women at increased risk of breast cancer. This led to an interest in cancer genetics, in pursuit of which she has taken both the Basic and the Advanced Course for Nurses in Genetic Cancer Risk Counseling at the Fox Chase Cancer Center. She joined the Clinical Genetics Branch in 2000, where she is currently involved in multiple clinical and epidemiologic studies aimed at understanding hereditary cancer and at better understanding the psychosocial impact of individuals identified as being at high genetic risk of cancer. In September 2008, Dr. Loud was appointed Assistant Branch Chief, Clinical Genetics Branch. She is also a member of NCI's Clinical Center Institutional Review Board and of the Gynecologic Oncology Group Nursing Committee.

Research Interests

Current research interests include assessing the impact of risk identification and risk management as they affect various aspects of an at-risk individual's life, with a particular focus on hereditary breast and ovarian cancer. Dr. Loud is also a co-investigator on CGB's Familial Testicular Cancer study, and the National Ovarian Cancer Prevention and Early Detection study (GOG-199). As CGB investigates the clinical implications of carrying mutations in cancer susceptibility genes, and develops novel approaches to risk management, she also hopes to learn how these strategies affect individuals and their families. She is studying how specific factors impact complex decisions related to cancer risk assessment, cancer risk communication, and activities of cancer prevention and control made by individuals at increased risk of cancer.

Selected Publications

• Loud JT. Direct-to-consumer genetic and genomic testing: Preparing nurse practitioners for genomic healthcare. J Nurse Pract, in press.
• Gierach GL, Loud JT, Chow CK, Prindiville SA, Eng-Wong J, Soballe PW, Giambartolomei C, Mai PL, Galbo CE, Nichols K, Calzone KA, Vachon C, Gail MH, Greene MH. Mammographic density does not differ between unaffected BRCA1/2 mutation carriers and women at low-to-average risk of breast cancer. Breast Cancer Res Treat 2010 Aug;123(1):245-55.
• Alter BP, Giri N, Savage SA, Peters JA, Loud JT, Leathwood L, Carr AG, Greene MH, Rosenberg PS. Malignancies and survival patterns in the National Cancer Institute inherited bone marrow failure syndromes cohort study. Br J Haematol 2010 Jul;150(2):179-88.
• Korde LA, Mueller CM, Loud JT, Struewing JP, Nichols K, Greene MH, Mai PL. No evidence of excess breast cancer risk among mutation-negative women from BRCA mutation-positive families. Breast Cancer Res Treat 2010 May 11.
• Loud JT, Hutson S. Chapter 7: Genetic Risk and Hereditary Cancer Syndromes. In: Yarbro CH, Wujcik D, Gobel GH eds. Cancer Nursing: Principles and Practice. Sudbury, Massachusetts: Jones and Bartlett, 2010.
• Koehly LM, Peters JA, Kenen R, Hoskins LM, Ersig AL, Kuhn NR, Loud JT, Greene MH. Characteristics of health information gatherers, disseminators, and blockers within families at risk of hereditary cancer: implications for family health communication interventions. Am J Public Health 2009 Dec;99(12):2203-9.
• Loud JT, Han PKJ, Gierach GL, Greene MH. Invited commentary: Multiple cancer screening tests - what's a practicing clinician to do? Ann Fam Med 2009 Jul 8;7, electronic publication.
• Loud JT, Thiébaut AC, Abati AD, Filie AC, Nichols K, Danforth D, Giusti R, Prindiville SA, Greene MH. Ductal lavage in women from BRCA1/2 families: is there a future for ductal lavage in women at increased genetic risk of breast cancer? Cancer Epidemiol Biomarkers Prev 2009 Apr;18(4):1243-51.
• Loud JT, Beckjord EB, Nichols K, Peters J, Giusti R, Greene MH. Tolerability of breast ductal lavage in women from families at high genetic risk of breast cancer. BMC Womens Health 2009 Jul 14;9:20.
• Peters JA, Vadaparampil ST, Kramer J, Moser RP, Court LJ, Loud J, Greene MH. Familial testicular cancer: interest in genetic testing among high-risk family members. Genet Med 2006 Dec;8(12):760-70.
• Loud JT, Weissman NE, Peters JA, Giusti RM, Wilfond BS, Burke W, Greene MH. Deliberate deceit of family members: a challenge to providers of clinical genetics services. J Clin Oncol 2006 Apr 1;24(10):1643-6.
• Abati A, Greene MH, Filie A, Loud J, Prindiville S, Danforth D, Giusti RM. Quantification of the cellular components of breast duct lavage samples. Diagn Cytopathol 2006 Jan;34(1):78-81.
• Hutson S, Loud JT. Resource appendix: cancer genetics resources: a guide for nurses and patients. Semin Oncol Nurs 2004 Aug 1;20(3):213-5.
• Loud JT, Hutson SP. The art and science of cancer nursing in the genomic era. Semin Oncol Nurs 2004 Aug;20(3):143-4.
• Loud JT, Peters JA, Fraser M, Jenkins J. Applications of advances in molecular biology and genomics to clinical cancer care. Cancer Nurs 2002 Apr;25(2):110-22; quiz 123-4. Review.
• Peters J, Loud J, Dimond E, Jenkins J. Cancer genetics fundamentals. Cancer Nurs 2001 Dec;24(6):446-61; quiz 462. Review.

Collaborators

DCEG Collaborators

• Mark H. Greene, M.D.; Phuong L. Mai, M.S., M.D.; Gretchen Gierach, PhD, M.P.H.; June Peters, M.S., C.G.C.; Christian P. Kratz, M.D.; Lindsey Hoskins, PhD, L.G.M.F.T.

DCP Collaborator

• David B. Portnoy, PhD, M.P.H.;

Other Scientific Collaborators

• Sadie Hutson, R.N., C.R.N.P., PhD (East Tennessee State University)
• Paul Han, M.D., M.A., M.P.H. (Maine Medical Center)