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National Cancer Institute U.S. National Institutes of Health www.cancer.gov
About DCEG

Kai Yu, Ph.D.

Investigator

Location: Executive Plaza South, Room 8050
Phone: 301-594-7206
Fax: 301-402-0081
E-mail: yuka@mail.nih.gov

 Kai Yu, Ph.D.

Biography

Dr. Yu received a Ph.D. in biostatistics from the University of Pittsburgh in 2000. He had postdoctoral training in statistical genetics at Stanford University. He worked as a statistical geneticist at a biopharmaceutical company before becoming a Research Assistant Professor of Biostatistics at Washington University in St. Louis. He joined NCI in 2005 as a tenure-track investigator. He received the NIH merit award (2009)

Research Interests

  • Statistical methods for genetic epidemiology studies
  • Tree-based models and applications in molecular epidemiology studies
  • MCMC algorithms and applications in genetic studies
  • Poulation genetics

Keywords

Genetic association study, Tree-based model, MCMC algorithm; Data-mining methods; Population genetics

Selected Publications

  • Yu K, Martin R, Rothman N, Zheng T, Lan Q (2007) Two-sample comparison based on prediction error, with applications to candidate gene association studies; Ann Hum Genet 71: 107-118
  • Yu K, Chatterjee N, Wheeler W, Li QZ, Wang S, Rothman N, Wacholder S (2007) Flexible design for following-up positive findings Am J Hum Genet 81: 540-551
  • Li QZ, Yu K. (2008) Improved correction for population stratification in genome-wide association studies by identifying hidden population structures; Genet Epidemiol 32: 215-226
  • Li QZ, Zheng G, Li ZH, Yu K. (2008) Efficient approximation of P-value of the maximum of correlated tests, with applications to genome-wide association studies; Ann Hum Genet 72: 397-406
  • Yu K, Wang Z, Li QZ, Wacholder S, Hunter DJ, Hoover RN, Chanock S, Thomas G. (2008) Population substructure and control selection in genome-wide association studies; PLoS ONE 3(7):e2551
  • Li QZ, Wacholder S, Hunter DJ, Hoover RN, Chanock S, Thomas G, Yu K. (2009) Genetic background comparison using distance-based regression, with applications in population stratification evaluation and adjustment; Genet Epidemiol 33(5): 432-441
  • Li QZ, Zheng G, Liang X, Yu K. (2009) Robust tests for single marker analysis in case-control association studies; Ann Hum Genet 73(2): 245-252
  • Li QZ, Yu K. (2009) Inference on non-centrality parameter of truncated non-central chi-squared distribution; J. of Stat. Inf. & Plan 139: 2431-2444
  • Yu K, Wheeler W, Li Q, Berger AW, Caporaso N, Chatterjee, N, Chen J. A partially linear tree-based regression model for multivariate outcomes; Biometrics (in press)
  • Yu K, Li Q, Berger AW, Pfeiffer R, Rosenberg P, Caporaso N, Kraft P, Chatterjee N. Pathway analysis by adaptive combination of P-values; Genet Epidemiol (in press)