Biography

Dr. Yu received a Ph.D. in biostatistics from the University of Pittsburgh in 2000. He had postdoctoral training in statistical genetics at Stanford University. He worked as a statistical geneticist at a biopharmaceutical company before becoming a Research Assistant Professor of Biostatistics at Washington University in St. Louis. He joined NCI in 2005 as a tenure-track investigator. He received the NIH merit award (2009)

Research Interests

• Statistical methods for genetic epidemiology studies
• Tree-based models and applications in molecular epidemiology studies
• MCMC algorithms and applications in genetic studies
• Poulation genetics

Keywords

Genetic association study, Tree-based model, MCMC algorithm; Data-mining methods; Population genetics

Software:

• Extremely small P-value Evaluation for Resampling-based Test (EXPERT)
• Genetic pathway analysis software (ARTP)
• Bayesian model for Detecting Gene Environment interaction (BaDGE)

Selected Publications

• Yu K, Chatterjee N, Wheeler W, Li QZ, Wang S, Rothman N, Wacholder S (2007) Flexible design for following-up positive findings. Am J Hum Genet 81: 540-551
• Li QZ, Yu K (2008) Improved correction for population stratification in genome-wide association studies by identifying hidden population structures. Genet Epidemiol 32: 215-226
• Li QZ, Zheng G, Li ZH, Yu K (2008) Efficient approximation of P-value of the maximum of correlated tests, with applications to genome-wide association studies. Ann Hum Genet 72: 397-406
• Yu K, Wang Z, Li QZ, Wacholder S, Hunter DJ, Hoover RN, Chanock S, Thomas G (2008) Population substructure and control selection in genome-wide association studies. PLoS ONE 3(7):e2551
• Yu K, Li Q, Berger AW, Pfeiffer R, Rosenberg P, Caporaso N, Kraft P, Chatterjee N (2009) Pathway analysis by adaptive combination of P-values. Genet Epidemiol 33:700-709
• Yu K, Wheeler W, Li Q, Berger AW, Caporaso N, Chatterjee, N, Chen J (2010) A partially linear tree-based regression model for multivariate outcomes. Biometrics 66:89-96
• Zhang H, Olshwang S, Yu K (2010) Statistical inference on the penetrances of rare genetic mutations based on a case-family design. Biostatistics 11(3):519-532
• Yu K, Liang F, Ciampa J, Chatterjee N (2011) Efficient p-value evaluation for resampling-based tests. Biostatistics 12(3):582-93
• Yu K, Wcholder S, Wheeler W, Wang Z, Caporaso N, Landi MT, Liang F (2012) A flexible bayesian model for studying gene-environment interaction. PLoS Genetics 8:e1002482