Fangyi Gu, M.Med., Sc.D., joined the Genetic Epidemiology Branch (GEB) in May, 2010. Dr. Gu completed her Sc.D. in epidemiology from the Harvard School of Public Health in 2010 and earned a Master of Medicine from Peking Union Medical College in 2004 and a Bachelor of Medicine from Peking Medical University in 2001. She has collaborated on several epidemiological projects, including the recent GWAS of smoking behaviors led by DCEG and Harvard investigators, as well as an international multicenter association study of insulin like growth factor pathway genes with circulating IGF1/BP3 hormone levels. While at DCEG, Dr. Gu is working with Neil E. Caporaso, M.D., Chief of GEB, and colleagues on smoking exposure and genetic susceptibility in relation to lung cancer risk.
Paula Hyland, Ph.D., M.P.H. joined the Genetic Epidemiology Branch (GEB) in January, 2010 as the Northern Irish Cancer Prevention Fellow. Dr. Hyland received her Ph.D. in biomedical sciences from the University of Ulster, Coleraine, (UUC), in Northern Ireland (NI), studying the effects of dNTP pool imbalances on DNA replication and repair fidelity. She also has a B.Sc. in biomedical sciences from UUC. In 2009, she obtained her M.P.H. from Queen’s University Belfast, NI, which focused on the molecular epidemiology of esophageal adenocarcinoma (EA) and the alteration of chromatin modifiers and histone marks by HPV-16 E6/7 oncogenes. In November 2012, Dr. Hyland became a research fellow in GEB.
Dr. Hyland has a strong interest in investigating the association of genetic variation as well as epigenetic changes and the risk of melanoma and upper gastrointestinal (UGI) tract cancers. She is currently working with Xiaohong Rose Yang, Ph.D., M.P.H., GEB investigator, to examine genetic and epigenetic changes and risk of familial melanoma. Dr. Hyland received two DCEG Intramural Research awards and an NCI Director’s Innovation award for her projects examining constitutional epigenetic changes and mitochondrial DNA copy number and their relationships with melanoma risk in melanoma-prone families. Dr. Hyland is also working with Philip R. Taylor, M.D., Sc.D., senior investigator, GEB, to assess the relationship of genetic variation in gene pathways and noncoding RNAs with risk of esophageal and gastric cancers using SNP data from the UGI cancer GWAS, as well as gene expression and biomarker detection in the Barrett’s Esophagus Early Detection Study (BEEDS).
Carolyn Reyes-Guzman, M.P.H., joined the Genetic Epidemiology Branch (GEB) as a predoctoral CRTA fellow in November 2011. Prior to joining as a fellow, she worked with GEB as a special volunteer since December 2010. She received her B.A. in French from Santa Clara University in 1999, and her M.P.H. in epidemiology from George Washington University (GWU) in 2005. Her interest in tobacco prevention and cancer etiology led her to focus her master’s research on cancer prevention, and in May 2005, she defended her thesis on the effectiveness of the cancer prevention clinic at Washington Hospital Center in Washington, D.C. She is currently pursuing her Ph.D. in epidemiology at GWU. In GEB, Ms. Reyes-Guzman works with Neil E. Caporaso, M.D., Chief of GEB, and her dissertation work focuses on the epidemiology of light and intermittent smokers, their genetics, and lung cancer outcomes.
Hyuna Sung, Ph.D., M.A., joined the Genetic Epidemiology Branch (GEB) as a postdoctoral fellow in July 2013. She received her B.A. in 2002 and M.A. in biological sciences in 2004 at Seoul National University. There, she worked with Dr. Dongeun Park studying the role of the Rac guanine nucleotide exchange factor β-Pix and Dynamin in rat hippocampal neurons. She then obtained a B.A. in pharmacy from Kyunghee University in 2009 and received her Ph.D. in molecular epidemiology from the Department of Biomedical Sciences at the Seoul National University under the supervision of Dr. Daehee Kang, in 2013. Her doctoral research focused on the association between genetic variants in microRNA-related genes and breast cancer risk and a breast cancer risk prediction model incorporating established risk factors, previously identified genetic loci, and microRNA-related SNPs newly identified in the Seoul Breast Cancer Study. While completing her Ph.D. as a predoctoral intern at Vanderbilt University in 2011, she participated in analysis of breast cancer genome-wide association study project conducted by the Asian Breast Cancer Consortium. As part of her postdoctoral fellowship in GEB, Dr. Sung is working on studies to understand and integrate genetic susceptibility, somatic alterations, and tumor heterogeneity in breast cancer and upper gastrointestinal cancer under the mentorship of Philip R. Taylor, M.D., Sc.D., senior investigator, GEB, and Xiaohong Rose Yang, Ph.D., M.P.H., investigator, GEB.
Guoqin Yu, Ph.D., M.S., joined the Genetic Epidemiology Branch (GEB) and the Infections and Immunoepidemiology Branch (IIB) as a CRTA postdoctoral fellow in 2011. She received a B.S. in biology and computer science in 2001 and an M.S. in genetics from Zhejiang University/Beijing Institute of Botany in 2004. She went on to earn a Ph.D. in evolution, ecology and population biology from Washington University in St. Louis in 2009, under the direction of Dr. Barbara Schaal. As part of her doctoral studies, she researched the evolution of starch synthesis pathway genes in wild and cultivated rice, and the association between variation in starch genes and starch quality in rice. In order to improve her bioinformatics techniques, Dr. Guoqin performed postdoctoral research for Drs. Arlin Stoltzfus and John Moult at the University of Maryland, College Park, where she studied the evolution of prokaryotes genomes using population genetics tools.
Dr. Yu is interested in the relationship between human microbiomes and cancer. She is also interested in explaining the variation within/between human populations and their relationship with cancer. She is currently working on projects about smoking, the human microbiome and smoking-related cancer with Neil E. Caporaso, M.D., Chief of GEB, Christian C. Abnet, Ph.D., M.P.H., Chief and senior investigator, Metabolic Epidemiology Branch, and her mentors Alisa M. Goldstein, Ph.D., senior investigator, GEB, and James J. Goedert, M.D., senior investigator, IIB. She is also working with Dr. Goldstein and Allan Hildesheim, Ph.D., Chief of IIB, on a study of the genetic susceptibility of nasopharyngeal carcinoma (NPC) families in Taiwan. In 2013, Dr. Yu was awarded an NCI Director’s Intramural Innovation Award.