Research Training in Translational Genomics

Overview

The goal of the Laboratory of Translational Genomics (LTG) is to develop new approaches to the study of the genetic basis of cancer and its outcomes. LTG has developed expertise in bio-informatics and advanced genetic analyses with new platforms designed to test dense sets of single nucleotide polymorphisms (SNPs), which are the most common genetic variants in the human genome. Specifically, the laboratory has integrated approaches to identify and validate common SNPs and ancestral haplotypes, which could be used to dissect the genetic basis of disease susceptibility. LTG utilizes programs and approaches in population genetics, epidemiology and molecular evolution, which assist in the choice and analysis of genetic variants under study. Recently, the focus of LTG has shifted to dissect the genetic basis of SNP markers validated in large scale, genome-wide association studies (GWAS). This new approach can identify new regions to be studied in great detail and eventually applied to large molecular epidemiology studies to estimate the magnitude of the effect. It will also be possible to investigate the interaction between genes and environmental factors. View a summary of LTG's major areas of research.

For application details, see below. To discuss potential research opportunities, you may contact branch investigators directly. Meet fellows in the branch.

Qualifications

Postdoctoral and predoctoral fellowships are available.

Postdoctoral fellowships: Fellowship training is for up to 5 years under the supervision of NCI senior scientists. Individuals must hold either an M.D. or Ph.D. in genetics, epidemiology, bio-informatics, molecular biology or a related field. Individuals with laboratory experience and/or expertise in manipulating and analyzing dense genomic data sets are encouraged to apply. Individuals with clinical or epidemiologic training are encouraged to apply.

Predoctoral fellowships: Individuals must be enrolled in a doctoral program with a desire to complete their dissertation in LTG or have completed a master’s degree in a field relevant to the mission of LTG.

Post-baccalaureate fellowships: Fellowships are also available for individuals who have recently completed an undergraduate degree in biology, genetics or laboratory science.

Application Process

Postdoctoral and predoctoral fellowship applications in LTG are accepted on an ongoing basis. Fellowships in LTG are provided through the DCEG fellowship program. See the Fellowship Information page for an overview, qualifications, and application details. Branch-specific opportunities are listed below.

Current Training Opportunities

Postdoctoral and predoctoral positions are available.

Training Opportunity with a Specific Investigator

• Training in Translational Genomics to investigate the Biological Basis of Common Germline Risk Variants Identified Through Genome-Wide Association Studies
  A postdoctoral research opportunity is available for an individual with a strong background in molecular biology, genomics and genetics, who is interested in understanding the functional underpinnings of risk variants identified by genome-wide association studies (GWAS).