Christopher Kim, M.P.H., Ph.D., Postdoctoral Fellow, Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI) (NIH FARE Winner – 2013)
Title: Home kitchen ventilation, cooking fuels, and lung cancer risk in a prospective cohort of never smoking women in Shanghai, China
Description: Indoor air pollution (IAP) caused by poor ventilation, burning of solid fuels, and cooking oils has been associated with lung cancer risk in retrospective case-control studies. However, few studies were conducted in urban areas where rapid socio-economic development led to substantial modernization in kitchen ventilation and fuel use. Here, we report the association of cooking conditions, fuel use, oil use and risk of lung cancer in a recently developed urban population in a prospective cohort of women in Shanghai.
Jason Hoskins, Ph.D., Postdoctoral Fellow, Laboratory of Translational Genomics, DCEG
Title: Functional analysis of the chr13q22.1 pancreatic cancer risk locus reveals allele-specific effects on DIS3 expression
Description: The first two phases of the PanScan pancreatic cancer GWAS identified several risk variants across 4 loci. The most significant of these risk variants lies in a ~600kb gene desert. This talk will describe our identification of the likely functional variant in the region, as well as our characterization of its long-range, allele-specific effects on DIS3 gene expression. We show that DIS3 protein level in pancreatic tumors is associated with survival, which is consistent with our hypothesis that the functional risk variant in chr13q22.1 confers risk of pancreatic cancer through altered DIS3 expression.
Alison Mondul, Ph.D., M.S.P.H., Research Fellow, Nutritional Epidemiology Branch, DCEG, NCI (NIH FARE Winner – 2013)
Title: Genetic variation in the vitamin D pathway in relation to risk of prostate cancer – results from the Breast and Prostate Cancer Cohort Consortium (BPC3)