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Discovering the causes of cancer and the means of prevention

Cancer Epidemiology: From Pedigrees to Populations

Honoring 50 years of visionary leadership by Joseph F. Fraumeni, Jr., M.D.

The symposium honored the visionary leadership of Dr. Fraumeni, the founding director of the NCI Division of Cancer Epidemiology and Genetics. The conference provided an opportunity for scientific exchange by the leading experts in cancer epidemiology. Speakers highlighted critical findings made over the past 50 years, as well as opportunities for future research that have the potential to significantly advance our understanding of the causes of cancer. 


Stephen J. Chanock, M.D., Director, DCEG, National Cancer Institute

SESSION I: Search for Cancer Susceptibility Genes
Moderator: David Schottenfeld, M.D., University of Michigan

  • Li-Fraumeni Syndrome: Discovery and Future Challenges
    Louise C. Strong, M.D., University of Texas MD Anderson Cancer Center

  • Li-Fraumeni Syndrome: TP53 and Beyond
    David Malkin, M.D., The Hospital for Sick Children

  • Family Studies, Cancer Etiology, and Telomere Biology
    Sharon A. Savage, M.D., National Cancer Institute

  • A Tale of Two Genomes: Current Generation Approaches to Cancer Susceptibility
    Kenneth Offit, M.D., M.P.H., Memorial Sloan Kettering Cancer Center

SESSION II. High-Risk Populations and Insights into Carcinogenic Mechanisms 
Moderator: Margaret R. Spitz, M.D., M.P.H., Baylor College of Medicine

  • Transplant-Associated Immunosuppression and Cancer
    Eric A. Engels, M.D., M.P.H., National Cancer Institute

  • Hormonal Carcinogenesis Across the Life Course
    Robert N. Hoover, M.D., Sc.D., National Cancer Institute

SESSION III. Global Health: Opportunities for Epidemiologic Research 
Moderator: Brian E. Henderson, M.D., University of Southern California

  • Using Geographic Patterns to Discover Environmental Carcinogens
    William J. Blot, Ph.D., International Epidemiology Institute & Vanderbilt University

  • Lung Cancer and Indoor Air Pollution in China
    Nathaniel Rothman, M.D., M.P.H., M.H.S., National Cancer Institute

  • Polycyclic Hydrocarbons: A Unifying Hypothesis for Global Patterns of Esophageal Cancer?
    Christian C. Abnet, Ph.D., M.P.H., National Cancer Institute


  • Michael Thun, M.D., M.S., American Cancer Society
  • Michael M. Gottesman, M.D., National Institutes of Health
  • Harold E. Varmus, M.D., National Cancer Institute

(Agenda pdf, 82.9 KB)