Genetic Susceptibility and Second Primary Cancers

Genetic susceptibility and treatment-associated risk of second primary cancers

Molecular studies of second cancers, with a focus on gene-environment interactions with radiation and chemotherapy, include descriptions of the spectrum of TP53 mutations among leukemia patients previously treated with platinum-based chemotherapy, DNA repair and cell cycle regulatory gene polymorphisms among patients who develop secondary leukemia, and microsatellite instability in Hodgkin lymphoma patients who later develop lung or breast cancer.

REB investigators are actively pursuing additional research opportunities to evaluate genetic susceptibility to multiple primary cancers. Opportunities for post-doctoral fellows are likely to be available in the future as these projects are initiated.