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Discovering the causes of cancer and the means of prevention

Case-Control Study of Biliary Tract Cancer in Shanghai

This population-based multidisciplinary case-control study was conducted in Shanghai, China, from 1997 to 2002, to investigate the risk factors for biliary tract cancer. The study enrolled over 3,000 participants, including 643 case subjects with cancer (382 gallbladder, 192 bile duct, and 68 ampulla of Vater), 1,037 control subjects with gallstones and bile duct stones, and 959 healthy subjects randomly selected from the population. This study has yielded important etiologic leads for biliary tract cancer. DCEG investigators have reported that gallstones, a family history of gallstones, higher parity (for gallbladder cancer), obesity, diabetes, metabolic syndrome, a history of chronic liver conditions, and a history of cholecystitis are associated with increased risk of biliary tract cancer, while tea drinking and aspirin use are associated with reduced risk. Investigators also showed that chronic HBV infection is associated with a 2-fold risk of extrahepatic bile duct cancer.

For more information, contact Jill Koshiol.

Infections and Immunoepidemiology Branch – Research Areas