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Osteogenic Sarcoma Genome-wide Association Study

The retrospective, candidate gene association study now underway in collaboration with the U.S. Children's Oncology Group (COG) has grown and matured into an international genome-wide association study (GWAS). In part, this has been facilitated by rapid decreases in the per subject costs for large-scale genotyping, and the increasing sophistication of genotyping platforms, which now include more than 1,000,000 SNPs and a similar number of copy number variants (CNVs). The COG samples comprise the cornerstone of a large, international effort, led by the NCI, which will undertake a genome-wide association study of osteogenic sarcoma (OS). Identifying international investigators willing to contribute their OS-related samples and data will be critical to assembling the very large number of samples required to identify and validate candidate SNPs using a GWAS strategy.

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