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Male Breast Cancer Pooling Project

The etiology of male breast cancer has been difficult to investigate, given its relative rarity with an occurrence less than 1% that of female breast cancer. Most previous studies have involved case-control designs, raising questions about the possibility of recall bias. Analyses of individual prospective studies to identify risk factors are difficult given typically small numbers of accrued cases.  In an attempt to overcome these limitations and increase statistical power, we initiated the Male Breast Cancer Pooling Project. We have secured international collaborations resulting in the pooling of 21 studies which have provided more than 2,400 cases of this rare malignancy and 52,000 controls. We are currently exploring a variety of potential risk factors through assessment of questionnaire data and biologic material. View publications from the Male Breast Cancer Pooling Project.

DCEG Scientists

Louise A. Brinton, Ph.D., M.P.H.
Michael B. Cook, Ph.D.

Roni T. Falk, M.S.
Jay H. Lubin, Ph.D.

Collaborating Scientists

Valerie McCormack, Kenneth C. Johnson, Hakan Olsson, John T. Casagrande, Rosie Cooke, Susan M. Gapstur, Mia M. Gaudet, J. Michael Gaziano, Georgios Gkiokas,, Pascal Guenel, Brian E. Henderson, Albert Hollenbeck, Ann W. Hsing, Laurence N. Kolonel, Claudine Isaacs, Karin B. Michels, Eva Negri, Dominick Parisi, Eleni Th. Petridou, Malcolm C. Pike, Elio Riboli, Howard D. Sesso, Kirk Snyder, Anthony J. Swerdlow, Dimitrios Trichopoulos, Giske Ursin, Piet A. van den Brandt, Stephen K. Van Den Eeden, Elisabete Weiderpass, Walter C. Willett, Marianne Ewertz, David B. Thomas.

For more information, contact Louise Brinton.

Hormonal and Reproductive Epidemiology Branch - Research Areas