Research in Action
Mark Schiffman uses molecular epidemiology to predict and prevent cervical cancer. Video: Taking the Long View
Cervix
DCEG researchers conduct studies on cancers of the cervix, more commonly referred to as cervical cancer. The primary cause of cervical cancer is persistent infection with the human papillomavirus (HPV). Selected studies include:
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HPV Vaccine Trial in Costa Rica
A randomized, controlled phase III trial of a vaccine to prevent human papillomavirus (HPV) 16 and 18 infections and their associated cervical lesions in Costa Rica
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ALTS Immunology Study
A prospective study designed to identify biomarkers associated with a permissive versus protective immune response to low-grade cervical lesions
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Cervical Adenocarcinoma Case-Control Study
A multi-center case-control study of cervical adenocarcinomas and other rare histological forms of cervical cancer
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Study to Understand Cervical Cancer Early Endpoints and Determinants (SUCCEED)
A study to comprehensively assess biomarkers of risk for progressive cervical neoplasia, and thus develop a new set of biomarkers that can distinguish those at highest risk of cervical cancer from those with benign infection
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The Biopsy Study – A Study to Distinguish HPV Infection from Precancer
A collaborative study on colposcopic biopsy with aims to study cervical disease on the lesion level, optimize criteria for biopsy placement, and analyze the incremental benefit of taking multiple biopsies
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Cervical Cancer Screening Among HIV-Infected Women in India
A study to evaluate a cohort of HIV-infected women using two novel and potentially sustainable, lower-cost tests for accurate screening for cervical cancer
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Human Papillomavirus (HPV) Natural History, Genomics and Risk Assessment
Studies of human papillomavirus (HPV) natural history, genomics and risk assessment that led to advances in screening and clinical management