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Screening for CPG Methylation and Allele Loss on Chromosome 14q to Identify Candidate Tumor Suppressor Genes in Nasopharyngeal Carcinoma

The goal of this study is to follow-up on chromosomal regions identified from a genome-wide linkage analysis of nasopharyngeal carcinoma (NPC) families in Taiwan and an independent gene expression analysis of sporadic NPC tumors collected from a case-control study also conducted in Taiwan. Investigators in DCEG will use an integrated genetic and epigenetic approach to identify genes that are important for the development of NPC. The specific objectives include: 

  • To identify mechanisms associated with altered gene expression in NPC tumors at chromosomal regions identified by linkage and expression profiling by screening NPC tumors for promoter methylation and copy number changes. 
  • To narrow the region and/or number of genes on those regions potentially involved in NPC development.

For more information, contact Alisa Goldstein.

Genetic Epidemiology Branch - Research Areas