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Endometrial Cancer in Polish Women

• This multi-center case-control study of endometrial cancer evaluated the relationships with estrogen replacement therapy, cigarette smoking, alcohol consumption, anthropometric factors, dietary factors, physical activity, and use of oral contraceptives during 2001-2003 in Poland.
• Menopausal estrogen replacement therapy increased the risk of endometrial cancer, but combination estrogen-progestin use was associated with a lower risk than estrogen use alone.
• Alcohol consumption was inversely related to risk, particularly among younger women.
• Upper body obesity was directly related to endometrial cancer risk in a dose-response relationship. Inactivity was associated with increased risk. Analyses of dietary data revealed an increase in endometrial cancer with higher intakes of fat and a decrease with intake of complex carbohydrates.

Physical Activity, Sedentary Behavior, and Endometrial Cancer

• The NIH-AARP Diet and Health Study examined relationships of activity patterns with endometrial cancer incidence in over 100,000 women, ages 50-71 at baseline in 1995-1996, who completed a questionnaire capturing daily routine and vigorous physical activity.
• A second questionnaire, completed by over 70,000 women in 1996-1997, collected additional physical activity information.
• Over 1,000 primary incident endometrial cancers were identified from baseline through December 2003.
• No associations were observed with light to moderate, daily routine or occupational physical activities, but endometrial cancer risk did increase with the number of hours of daily sitting.