Patients with scoliosis undergo frequent diagnostic x-rays of the spine during childhood and adolescence to monitor for curve progression. Consistent with radiation etiology, risk of mortality from breast cancer increased significantly with increasing radiation dose to the breast in a cohort of 5,466 female scoliosis patients. An incidence analysis of breast cancer with an evaluation of reproductive factors that may affect the dose-response relationship was recently completed. The findings are slated for publication in the March 2008 edition of Cancer Epidemiology Biomarkers and Prevention. Breast cancer mortality and incidence risks were similar.
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