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Discovering the causes of cancer and the means of prevention

Renal Cancer Genome-wide Association Study (GWAS)

From the Cancer Genetic Markers of Susceptibility (CGEMS) Project

The National Cancer Institute (NCI) genome-wide association study (GWAS) of renal cell carcinoma (RCC) was conducted to investigate common genetic variants associated with RCC risk. The GWAS includes 1,453 RCC cases and 3,531 controls of European background from 4 studies (3 cohort, 1 case-control), scanned using the Illumina InfiniumHumanHap 550, 610 and 660W chips. This project was supported by the Intramural Research Program of the National Institutes of Health and NCI.

Data from this GWAS were pooled with those from another GWAS of RCC (2,639 cases and 5,392 controls) conducted in Europe by the International Agency for Research on Cancer and the Centre National de Gènotypage. Findings from this collaboration are described in Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3. Purdue et al. Nature Genetics 2011;43(1):60-65; PMID: 21131975.

Note: Only data from the NCI scan are included in this dbGaP submission.

Obtain additional information or apply for access to the Renal Cancer Genome-Wide Association Study