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Herbicide Exposure and Biologic Effects

Several, but not all, epidemiologic studies have noted an association between exposure to the herbicide 2,4-D and the risk of non-Hodgkin lymphoma. 2,4-D does not appear to cause cancer in laboratory animals and has not been demonstrated to clearly damage genetic material in experimental investigations. The association with non-Hodgkin lymphoma suggests the possibility of a mechanism involving the immune system. A collaborative study with the University of Kansas Medical School of 30 2,4-D applicators and 10 nonapplicators in Kansas is designed to evaluate this possibility. Blood and urine was taken before, during and after the herbicide application season to evaluate the possible association between urinary levels of 2,4-D and several biologic parameters.

For more information, contact Laura Beane Freeman.

Occupational and Environmental Epidemiology Branch - Research Areas