Viral and bacterial infections are known to cause a number of different malignancies in populations world-wide. DCEG carries out multidisciplinary studies of carefully selected populations in the United States and abroad, with the goal of clarifying the relationship of infectious agents, especially viruses, to human cancer and other conditions. Recent research has concentrated on human retroviruses (HIV-1), with additional studies on human papillomaviruses (HPV), hepatitis viruses, papovaviruses, and human herpesviruses (HHV), especially HHV-8.
A randomized, controlled phase III trial of a vaccine to prevent human papillomavirus (HPV) 16 and 18 infections and their associated cervical lesions in Costa Rica
A study to determine the impact of HPV vaccination in preventing infections in the oral, vulvar, and anal regions
A study of anal cancer risk in HIV-positive men who have sex with men
A study of the clinical management of low-grade cervical cytologic abnormalities
A multi-center case-control study of cervical adenocarcinomas and other rare histological forms of cervical cancer
A study to comprehensively assess biomarkers of risk for progressive cervical neoplasia, and thus develop a new set of biomarkers that can distinguish those at highest risk of cervical cancer from those with benign infection
A collaborative study on colposcopic biopsy with aims to study cervical disease on the lesion level, optimize criteria for biopsy placement, and analyze the incremental benefit of taking multiple biopsies
A study to evaluate a cohort of HIV-infected women using two novel and potentially sustainable, lower-cost tests for accurate screening for cervical cancer
HIV/AIDS cancer match study examines cancer risk among people living with HIV infection in the United States.
Studies that address unresolved questions on the genomic integrity of Kaposi sarcoma (KS) and whether multiple tumors in individuals are clonal
Studies of Kaposi sarcoma-associated herpesvirus transmission and prevalence in Uganda
Epstein-Barr virus and genetics in AIDS-related non-Hodgkin lymphoma
A large, multidisciplinary epidemiological effort designed to evaluate environmental and host factors associated with childhood Burkitt lymphoma in sub-Saharan Africa
DCEG studies of Epstein-Barr virus (EBV) and gastric cancer
DCEG studies of lung cancer and infectious agents, including Chlamydophila pneumonia