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Hereditary Cancer Syndromes

DCEG researchers study a range of inherited syndromes that may predispose affected individuals and their family members to cancer. These include inherited bone marrow failure syndromes, Li-Fraumeni Syndrome, dyskeratosis congenita, and other inherited cancer predisposition syndromes. We use an interdisciplinary clinical research approach to systematically investigate of cancers related to these syndromes.

  • Chordoma Study

    A study of familial and non-familial chordoma, a rare bone cancer

  • Pleuropulmonary Blastoma (PPB) Cancer Predisposition Syndrome

    A natural history study on Pleuropulmonary Blastoma (PPB) Cancer Predisposition Syndrome. The DICER1 syndrome is characterized by rare benign and malignant tumors, such as pleuropulmonary blastoma (PPB).

  • Familial Blood and Lymph Node Cancers Study

    A study of a group of familial blood and lymph node cancers (also called "lymphoproliferative disorders"), including: chronic lymphocytic leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, Waldenström's macroglobulinemia, and multiple myeloma

  • Familial Testicular Cancer Study

    A study evaluating the role of testicular microlithiasis in familial testicular cancer

  • Inherited Bone Marrow Failure Syndromes (IBMFS)

    A study of inherited bone marrow failure syndromes (IBMFS), a group of rare genetic blood disorders that include Fanconi Anemia, Dyskeratosis Congenita, Diamond-Blackfan Anemia, Shwachman-Diamond Syndrome, Severe Congenital Neutropenia, Amegakaryocytic Thrombocytopenia, and Thrombocytopenia Absent Radii.

  • Li-Fraumeni Syndrome Study

    A clinical study and multi-institutional collaboration for research on Li-Fraumeni Syndrome

  • Melanoma

    DCEG is conducting research on melanoma, a form of skin cancer.