DCEG researchers study a range of inherited syndromes that may predispose affected individuals and their family members to cancer. These include inherited bone marrow failure syndromes, Li-Fraumeni Syndrome, dyskeratosis congenita, and other inherited cancer predisposition syndromes. We use an interdisciplinary clinical research approach to systematically investigate of cancers related to these syndromes.
A study of familial and non-familial chordoma, a rare bone cancer
A natural history study on Pleuropulmonary Blastoma (PPB) Cancer Predisposition Syndrome. The DICER1 syndrome is characterized by rare benign and malignant tumors, such as pleuropulmonary blastoma (PPB).
A study of a group of familial blood and lymph node cancers (also called "lymphoproliferative disorders"), including: chronic lymphocytic leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, Waldenström's macroglobulinemia, and multiple myeloma
A study evaluating the role of testicular microlithiasis in familial testicular cancer
A study of inherited bone marrow failure syndromes (IBMFS), a group of rare genetic blood disorders that include Fanconi Anemia, Dyskeratosis Congenita, Diamond-Blackfan Anemia, Shwachman-Diamond Syndrome, Severe Congenital Neutropenia, Amegakaryocytic Thrombocytopenia, and Thrombocytopenia Absent Radii.
A clinical study and multi-institutional collaboration for research on Li-Fraumeni Syndrome
DCEG is conducting research on melanoma, a form of skin cancer.