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Methodologic Study of Tissue Hormones

DCEG investigators are carrying out a multi-racial methodologic study in the U.S. and China to investigate whether serum levels of hormones reflect intraprostatic androgenicity. A total of 600 subjects, including African Americans, Caucasians, Asian Americans, and Chinese men living in China, diagnosed with prostate cancer, benign prostatic hyperplasia, or bladder cancer undergoing prostatectomy will be recruited for tissue and blood collection. Hormone levels in prostatic tissue will be measured and compared with serum levels and polymorphisms of hormone-related genes. Levels of androgen receptor and its associated proteins in prostate tissue will be measured directly. In addition, factors such as age, smoking, and body size that might alter serum-tissue correlations will be examined. Possible racial variation in the serum-tissue correlations will also be assessed. This study is the first of its kind to investigate androgenicity in target tissue directly and will help guide future epidemiologic studies on prostate cancer.

For more information, contact Michael Cook.

Hormonal and Reproductive Epidemiology Branch - Research Areas