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Power for Genetic Association Analyses (PGA)

PGA is a package of algorithms and graphical user interfaces developed in Matlab for power and sample size calculation under various genetic models and statistical constraints. The software is designed to facilitate decision making for case-control association studies of candidate genes, fine-mapping studies, and whole-genome scans.

Download Software:

PGA is a package of algorithms and graphical user interfaces developed in Matlab for power and sample size calculation under various genetic models and statistical constraints. The software is designed to facilitate decision making for case-control association studies of candidate genes, fine-mapping studies, and whole-genome scans.

  1. Users without Matlab software should install first the MATLAB Component Runtime (MCR): MCRInstaller
  2. Download the self extracting zip file for PGA
  3. Save this file in an appropriate folder on your disk.
  4. Click on it, and the PGA files will be extracted to a designated location on your hard drive.

Reference:

Please cite the following reference when reporting results obtained from PGA:
Menashe I., Rosenberg P.S., and Chen B.E. (2008) PGA: Power calculator for case-control genetic association analyses. BMC Genetics, 9:36.

Support:

For questions regarding the PGA tool, please email Dr. Philip Rosenberg.

Updates and Bug Fixes:

  • September 9th 2008 - PGA1 was updated to fix a bug that caused a bias in the power calculation for a co-dominant (1df) model.
  • July 29th 2008 - EDF was updated to fix a bug that generated an error message when genotype input files were uploaded.