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Discovering the causes of cancer and the means of prevention
 

Bioinformatics Scientist in Cancer Genomics (Contractor), Integrative Tumor Epidemiology Branch

The Integrative Tumor Epidemiology Branch (ITEB) of the NCI Division of Cancer Epidemiology and Genetics (DCEG) is seeking a bioinformatics scientist. The ITEB mission is to conduct large-scale, international epidemiological research on cancer etiology and progression through integrative analyses of risk factors and tissue profiling to inform prevention and clinical strategies. Learn more about the ITEB program of research.   

Position Description 

The bioinformatics scientist will work closely with Diptavo Dutta, Ph.D., Earl Stadtman tenure-track investigator, and in collaboration with other principal investigators, senior bioinformaticians and epidemiologists within ITEB and across other branches in DCEG. They will be responsible for accessing and analyzing large genetic and genomic databases from current and past studies. This includes but is not limited to data manipulation, algorithmic implementation, statistical programming, genetic/genomic analyses, and presenting results to scientific community within and beyond DCEG.  

The position will provide support and expertise in installing, troubleshooting, and running analytical pipelines using open-source scientific software on Unix/Linux and Cloud-based platforms, and using publicly available bioinformatics and genomic databases and analysis pipelines. Data types can include genome-wide genotyping arrays, DNA sequencing, gene expressions, proteomic profiling, and methylation profiling, across a range of tissues and cancer types.   

Qualifications   

Required qualifications:  

  1. Master’s degree in bioinformatics, computational biology, data science or a related field 
  2. Extensive programming experience in at least two of R, Python and C++. 
  3. Familiarity with Unix/Linux system, bash or similar scripts and high performance computing clusters 
  4. Team oriented with excellent written and verbal communication skills, with demonstrated ability to learn and adopt bioinformatics techniques and resources. 

Preferred qualifications:  

  1. Experience in processing and analyzing large genetic and genomic files (VCFs, PLINK binary) 
  2. Experience in whole exome/genome sequencing analysis (such as mutation, copy number and variant calling) 
  3. Experience in standard genetic association analysis software like PLINK, GCTA etc. 
  4. Familiarity and working knowledge of tools to query and investigate cancer genomics with publicly available data sources (such as dbGaP, TCGA, ENCODE, 1000 Genomes, GTEX, gnomAD, cBioPortal, TCPA) 
  5. Experience in performing statistical analysis of large datasets by running open source and custom developed analysis pipelines in R/Python/C++. 

Additional Details 

The NCI is an exciting place to work, and the position provides excellent learning opportunities and possibilities for professional advancement. Pay is commensurate with qualifications and includes a comprehensive benefit package. This is a contract position at a government agency in Rockville, Maryland.  

To Apply 

Please send resume and cover letter addressing your qualifications for the position to Ms. Sylvia Roberts with “Bioinformatics Scientist Application” in the subject line. The ending date for applications is November 30, 2022, or until the position is filled.