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Discovering the causes of cancer and the means of prevention

Gastric Cancer Research in the Infections and Immunoepidemiology Branch

Gastric (stomach) cancer occurs when cancer cells form in the lining of the stomach. Increased incidence of noncardia gastric cancer among specific populations in the U.S. have led investigators in the Infections and Immunoepidemiology Branch (IIB) to study serologic screening markers, pathogenic microbes and molecular pathology in order to increase knowledge of disease etiology and decrease the burden of disease. Selected studies include:

Autoimmune Gastritis

DCEG investigators in the Infections and Immunoepidemiology Branch (IIB) have documented unprecedented increases of noncardia gastric cancer among younger generations in the U.S. Analyses of incidence trends reveal a coherent set of features that suggest autoimmune gastritis may be the underlying cause. Further efforts are underway. Read more about Autoimmune Gastritis and Gastric Cancer.

H. pylori Genome Project (HpGP)

DCEG investigators in IIB and the Metabolic Epidemiology Branch are undertaking a joint effort to catalog comprehensively bacterial genetic and epigenetic variation potentially related to long-term outcomes of infection. Read more about the H. pylori Genome Project.

EBV-Associated Gastric Cancer

Studies evaluating gastric cancers associated with the Epstein-Barr virus (EBV) infection. Read more about EBV-associated Gastric Cancer.

NCI International EBV-Gastric Cancer Consortium

A collaboration among NCI and extramural investigators, established by DCEG in 2006, that utilizes data and biospecimens from 18 completed and ongoing case series and observational studies of gastric cancer to replicate and extend findings from previous studies hindered by small numbers of EBV-positive cases, and to stimulate multidisciplinary research in this area. Read more about the NCI International EBV-Gastric Cancer Consortium.