Human papillomavirus (HPV) causes a number of cancers, including cervical cancer, which is one of the leading causes of cancer incidence and death globally, and oropharyngeal cancer (OPC), which is one of the fastest increasing cancers in the Unites States. Researchers in the Infections and Immunoepidemiology Branch (IIB) are investigating primary prevention via prophylactic HPV vaccination. Selected studies include:
A randomized, controlled phase III trial of a vaccine to prevent human papillomavirus (HPV) 16 and 18 infections and their associated cervical lesions in Costa Rica. Learn more about the HPV Vaccine Trial in Costa Rica.
A study to determine the impact of HPV vaccination in preventing infections in the oral, vulvar, and anal regions. Learn more about HPV vaccine effiicacy at extracervical sites.
Study to evaluate the efficacy of one or two doses of the bivalent or nonavalent prophylactic HPV vaccines. Learn more about the ESCUDDO Study.