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Discovering the causes of cancer and the means of prevention
 

Liver Cancer Research in the Metabolic Epidemiology Branch

Liver cancer is the sixth most commonly occurring cancer in the world and due to a very poor prognosis, the second largest contributor to cancer mortality. Liver cancer is composed of two major histologic types: hepatocellular carcinoma (HCC, ~70%) and intrahepatic cholangiocarcinoma (ICC, ~15%).  The incidence of both types has been increasing in many countries for the past several decades. MEB investigators conduct research on a variety of factors in relationship to liver cancer including:

  • Metabolic conditions (e.g., obesity, diabetes, and metabolomic syndrome)
  • Exogenous and endogenous hormonal exposures
  • Diet
  • Coffee
  • Cigarette smoking
  • Medications
  • Hepatitis B virus and hepatitis C virus (HBV/HCV)
  • Aflatoxins (AFB1)
  • Metabolomics (including lipidomics, bile acids, and fatty acids)
  • Microbiome (including circulating markers of bacterial translocation)

MEB investigators are conducting liver cancer studies using the following resources:

Learn about the Liver Cancer Pooling Project (LCPP)
A pooling project of prospective cohort studies that seeks to understand the factors behind the rising incidence of HCC and ICC in the U.S.

For more information, contact Katherine McGlynn or Neal Freedman.