Figure 1. Pedigree of Family A from the first paper documenting the constellation of tumors in what would later be known as Li-Fraumeni syndrome. This family developed a remarkable combination of multiple cancers in children and young adults, including soft tissue sarcomas and breast cancer. The proband, noted by an arrow, was the first affected individual identified in the study. From Li F, Fraumeni JF, Jr. Annals of Internal Medicine 1969.