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Discovering the causes of cancer and the means of prevention

Epigenetic Mechanisms of Breast Cancer Risk - James Flanagan

DCEG Seminar Series

Title:  Epigenetic Mechanisms of Breast Cancer Risk

Speaker: James M. Flanagan, Ph.D. Non-Clinical Senior Lecturer, Faculty of Medicine, Department of Surgery & Cancer, Division of Cancer Epigenetics Unit, Imperial College London

   Host: Dr. Montserrat Garcia-Closas, M.D., Dr.P.H., Deputy Director, Division of Cancer Epidemiology and Genetics, NCI

Description:  In his presentation Dr. Flanagan will discuss the field of epigenetic epidemiology. It has rapidly advanced and recent work has discovered epigenetic markers of cancer risk in white blood cell (WBC) DNA. Using Epigenome-Wide Association Studies (EWAS) on the Illumina 450k methylation array, he and others have shown epigenome-wide hypomethylation in incident breast cancer cases compared with controls in several prospective cohorts. He has proposed a mechanism that involves cancer risk exposures, lifetime and environmental events, that alter the epigenome and stably modifies an individual's cancer risk. He has now expanded on this work by using whole genome bisulphite sequencing (WGBS) and target capture bisulphite sequencing (TCBS) and these new data provide a significant advance in identifying which parts of the epigenome are associated with breast cancer risk.


In addition to the seminar, Dr. Flanagan will participate in a round table discussion and he will be available for individual meetings.

Roundtable Discussion

Topic: DNA Methylation and Cancer Risk

Time: 1:00 to 2:30 P.M.  and  Location: 7E 032/034 

Please contact Ka Lai Lou (ka.lou@nih.gov) if you would like to meet with Dr. Flanagan during his visit.