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People in the News

July 2013 - Linkage Newsletter

In April, Blanche P. Alter, M.D., M.P.H., Clinical Genetics Branch (CGB), shared her expertise on “Incidence of non-head and neck solid tumors in Fanconi Anemia” at a consensus conference on revisions for the fourth edition of Fanconi Anemia: Guidelines for Diagnosis and Management. The conference, held in Washington, D.C., was sponsored by the Fanconi Anemia Research Fund.

In January, Laufey Amundadottir, Ph.D., Laboratory of Translational Genomics (LTG), spoke on “Pancreatic cancer genetics: GWAS, fine-mapping and functional characterization of the chr5p15.33/CLPTM1L/TERT risk locus” at the Spanish National Cancer Research Center in Madrid and at the Bellvitge Biomedical Research Institute in Barcelona, Spain. She spoke on the same topic in March at the Pancreatic Cancer Case-Control Consortium annual meeting at Johns Hopkins University in Baltimore, Maryland.

In February, Hannah Arem, Ph.D., Nutritional Epidemiology Branch (NEB), successfully defended her doctoral dissertation at the Yale School of Public Health in New Haven, Connecticut. She conducted the research for her thesis project, “Pancreatic cancer: An examination of dietary and genetic risk factors,” under the supervision of Joshua Sampson, Ph.D., Biostatistics Branch (BB), and Rachael Stolzenberg-Solomon, Ph.D., M.P.H., R.D. (NEB), along with Dr. Arem's mentors from Yale, Dr. Susan T. Mayne and Dr. Harvey Risch. Dr. Arem is now a postdoctoral fellow in NEB under the mentorship of Charles Matthews, Ph.D.

In December, Kevin Brown, Ph.D. (LTG), gave a seminar on the “Genetic basis of melanoma” at The Wistar Institute in Philadelphia, Pennsylvania.

In April, Neil E. Caporaso, M.D., Chief of the Genetic Epidemiology Branch (GEB), gave a talk titled “Preventing and curing cancer: So close, yet so far” at the St. John Medical Center symposium on Celebrating the Art of Healing in Tulsa, Oklahoma.

In February, Stephen J. Chanock, M.D., Chief of LTG and Director of the NCI Cancer Genomics Research Laboratory, gave a Director’s Lecture at the Vanderbilt-Ingram Cancer Center in Nashville, Tennessee. In March, he gave lectures at the Institute of Endocrinology and Metabolism in Kiev, Ukraine, and the German Society of Human Genetics annual meeting in Dresden, Germany.

In April, Anil K. Chaturvedi, Ph.D., Infections and Immunoepidemiology Branch (IIB), gave a talk titled “HPV-associated non-cervical cancers: Burden and prevention potential” at the 2013 Experimental Biology Meeting’s Presidential Symposium in Boston, Massachusetts.

In November, Charles Chung, Ph.D. (LTG), gave a presentation titled “Meta-analysis of GWAS identifies four new loci for testicular germ cell tumor” at the 2012 American Society of Human Genetics annual meeting in San Francisco, California.

In January, Mitchell H. Gail, M.D., Ph.D. (BB), gave an invited talk on “Using risk models for breast cancer prevention” for the President’s Research Seminar series at the Memorial Sloan-Kettering Cancer Center in New York, New York.

In March, several DCEG fellows gave presentations at the American Society of Preventive Oncology’s 37th Annual Meeting in Memphis, Tennessee. Todd M. Gibson, Ph.D., Radiation Epidemiology Branch (REB), spoke on “Predictors of colorectal cancer surveillance among radiation-treated survivors of childhood cancer”; Jonathan Hofmann, Ph.D., Occupational and Environmental Epidemiology Branch, spoke on “A prospective study of circulating adipokine levels and risk of multiple myeloma”; Cari Meinhold Kitahara, Ph.D. (REB), gave presentations on “Obesity and thyroid cancer risk among U.S. men and women” and “Childhood height and weight and thyroid cancer risk in the Copenhagen School Health Records Register Cohort”; and Lisa Mirabello, Ph.D. (CGB), gave a talk titled “The association of telomere length and cancer.”

In March, James J. Goedert, M.D. (IIB), spoke on “Kaposi’s sarcoma-associated herpesvirus, Kaposi’s sarcoma, and multicentric Castleman disease: Epidemiologic perspectives” at the Multicentric Castleman Disease Workshop in Rockville, Maryland.

In November, Lauren Houghton, Ph.D., an NIH-Wellcome Trust Fellow in the Epidemiology and Biostatistics Program (EBP), successfully defended her doctoral dissertation at Durham University in the United Kingdom. She conducted her doctoral research, titled “Juvenility, puberty and adolescence among Bangladeshi and British youth,” under the joint mentorship of Robert N. Hoover, M.D., Sc.D., Director of EBP; Hormuzd A. Katki, Ph.D. (BB); Rebecca Troisi, Sc.D. (EBP); Regina G. Ziegler, Ph.D., M.P.H. (EBP); and her mentors from Durham University, Dr. Gillian Bentley, Dr. Mark Booth, and Dr. Kate Hampshire. Dr. Houghton will continue as a postdoctoral fellow in the Division.

In February, Indu Kohaar, Ph.D. (LTG), gave a guest lecture titled “From genotype to phenotype: Role of SNPs in disease risk” for an undergraduate course on Biology of Health Disparities at the University of the District of Columbia.

In April, Jill Koshiol, Ph.D. (IIB), presented a poster titled “Bile and serum immune-related markers associated with gallbladder cancer” at the third annual CanLiv Research Symposium in Washington, D.C.

In April, Aimée R. Kreimer, Ph.D. (IIB), gave a talk on “HIV vaccination: Adherence and impact in reducing cancer burden in Hispanics” at the Decreasing Health Disparities in Cancer Prevention & Diagnosis among High-Risk Populations meeting in San Juan, Puerto Rico.

In February, Sam M. Mbulaiteye, M.D. (IIB), gave a talk titled “AIDS-cancer match studies—Challenges and opportunities in developing countries: Lessons from the Uganda experience” at the second Workshop on HIV and Cancer in Pune, India.

June A. Peters, M.S., C.G.C. (CGB), helped organize the 13th International Meeting on Psychosocial Aspects of Hereditary Cancer, held in Sydney, Australia, in March. At the meeting, she moderated a session on melanoma genetics and presented a case report on a Li-Fraumeni syndrome family.

Ruth M. Pfeiffer, Ph.D. (BB), presented a lecture titled “On criteria for evaluating risk prediction models for public health applications” in January for the Department of Biostatistics at the University of North Carolina Gillings School of Global Public Health in Chapel Hill; in March at the Eastern North American Regional Spring Meeting of the International Biometric Society in Orlando, Florida; and in March at the Deutsche Arbeitsgemeinschaft Statistik (DAGStat) Third Joint Statistical Meeting in Freiburg, Germany. Also at the DAGStat meeting, Mitchell H. Gail, M.D., Ph.D. (BB), spoke on “Some applications of risk modeling in medicine and public health.”

In December, Ludmila Prokunina-Olsson, Ph.D. (LTG), was selected for Genome Technology magazine’s Seventh Annual Young Investigators list. The list highlights future leaders in the field of genomics. In addition, Dr. Prokunina-Olsson’s research was featured in two articles in the January 8 issue of the NCI Cancer Bulletin (Archive):Newly Discovered Gene Linked to Hepatitis C Virus Clearance, Treatment Response” (with Thomas R. O’Brien, M.D., M.P.H. [IIB]) and “Following Up on Genetic Study, Researchers Identify Potential Therapy for Bladder Cancer.”

Ludmila Prokunina-Olsson, Ph.D. (LTG), spoke about the novel human interferon IFNL4 at an NIH Translational Interest Research Group seminar in Bethesda, Maryland, in February; at an NCI Center for Cancer Research seminar in Bethesda, Maryland, in March; at the Receptors and Cytokines in Innate Immunity symposium hosted by the NIH Natural Killer Cell Interest Group, the NIH Cytokine Interest Group, and the NIH Immunology Interest Group in Bethesda, Maryland, in April; and at the U.S. Food and Drug Administration’s Division of Therapeutic Proteins in Bethesda, Maryland, in April. She also gave a presentation on “Making GWAS findings translational: From p-values to clinical applications for bladder cancer and management of HCV infection” at the University of Hawaii Cancer Center in Honolulu in February. In April, Dr. Prokunina-Olsson gave a presentation titled “Find your own novel interferon: The story of interferon lambda 4 (IFNL4)” at a meeting of the NIH RNASeq Special Interest Group in Bethesda, Maryland. Also at the meeting, Wei Tang, Ph.D. (LTG), spoke on “RNA sequencing: Our lessons and future directions.”

In May, four DCEG fellows presented posters at the 2013 NIH Postbac Poster Day, sponsored by the NIH Office of Intramural Training and Education. Hilary Robbins (IIB) received special recognition for her poster “Utility of glutathione s-transferase multiplex serology as a measure of exposure and immunity to human papillomavirus among unvaccinated women” with mentor Mahboobeh Safaeian, Ph.D. (IIB), which scored among the top 20 percent of those presented. In addition, Luyang Liu (LTG) presented “Geographic analysis of non-synonymous genetic variants in IFNL4 gene in The 1000 Genomes Project populations” with mentor Ludmila Prokunina-Olsson, Ph.D. (LTG); Daphne C. Papathomas, Hormonal and Reproductive Epidemiology Branch (HREB), presented “The aging breast: Quantitative analysis of lobular involution” with mentors Jonine D. Figueroa, Ph.D., M.P.H. (HREB), and Mark E. Sherman, M.D. (formerly of HREB); and Alan Wang (IIB) presented “Association of the IFNL4 delta-G allele with impaired clearance of HCV infection” with mentor Thomas R. O’Brien, M.D., M.P.H. (IIB).

In March, Vikrant V. Sahasrabuddhe, M.B.B.S., Dr.P.H. (HREB), gave an invited presentation on “Cervical cancer prevention in HIV-infected women in India” as part of a symposium on Cervical Cancer Screening and Treatment in HIV-Infected Women in Resource Limited Settings at the 4th Annual Conference of the Consortium of Universities for Global Health in Washington, D.C.

In February, Sharon A. Savage, M.D. (CGB), presented “Understanding pulmonary fibrosis through studies of dyskeratosis congenita” at the Interdisciplinary Approaches to Idiopathic Lung Fibrosis meeting at the Cold Spring Harbor Laboratory in Long Island, New York.

In February, Catherine Schairer, Ph.D. (BB), spoke on “Inflammatory breast cancer: Evidence for a distinct disease?” during grand rounds at the University of Nebraska Medical Center in Omaha.

In April, Meredith Shiels, Ph.D. (IIB), was selected to give a talk for the Outstanding Achievement in Science seminar series, hosted by the NCI Fellows and Young Investigators Steering Committee. She gave a presentation on “Cancer trends in HIV-infected individuals” and was recognized for her work on HIV and cancer.

In March, Nicolas Wentzensen, M.D., Ph.D., M.S. (HREB), gave an invited talk on “Finding cervical precancer: Evaluation of novel biomarkers and colposcopy” at the University of Minnesota Gynecologic Oncology Spring Research Symposium in Minneapolis, Minnesota. In April, he co-chaired the Ovarian Cancer Cohort Consortium meeting in Washington, D.C.

In February, Xiaohong Rose Yang, Ph.D., M.P.H. (GEB), spoke on “Difference in breast cancer risk factor associations in breast cancer subtypes in population-based studies” at the Chinese University of Hong Kong. In March, she gave presentations on “Characterization of genetic variants in the T gene in familial and sporadic chordoma” at the Fourth International Chordoma Research Workshop and on “The search for susceptibility genes for familial melanoma” at Harvard Medical School in Boston, Massachusetts.

In February, Guoqin Yu, Ph.D. (GEB), presented a poster titled “Association between upper digestive tract microbiota and precancerous conditions in the esophagus and stomach” at The Gut Microbiome: The Effector/Regulatory Immune Network meeting presented by the Keystone Symposia on Molecular and Cellular Biology in Taos, New Mexico.

Back to the July 2013 issue of Linkage