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Discovering the causes of cancer and the means of prevention

Randomized Trial to Evaluate Proton Versus Photon for Treatment of Breast Cancer

Amy Berrington de González

Amy Berrington de Gonz├ílez, D.Phil., Chief of the Radiation Epidemiology Branch, is co-leading the late-effects working group on a new 20 center randomized trial to compare the effectiveness of proton beam versus traditional photon radiotherapy in treating breast cancer and minimizing collateral damage to healthy organs and tissue, like the heart. Traditional photon based radiotherapy reduces breast cancer mortality and recurrence but can elevate the risk of future heart problems. Choonsik Lee, Ph.D., also of DCEG, will be a key collaborator on the trial, contributing his expertise in reconstructing radiation doses to the heart and other organs from these complex radiotherapy procedures. The project is coordinated by Dr. Justin Bekelman at the University of Pennsylvania and funded through the Patient-Centered Outcomes Research Institute (PCORI).