The Collaborative Breast Cancer Study (CBCS) is a population-based case-control study of breast cancer in the states of Wisconsin, Massachusetts and New Hampshire. The main goal of this study is to evaluate susceptibility factors for breast cancer risk and their interactions with environmental risk factors. Enrollment and data collection started in June 1998 and was completed in April 2001. The CBCS obtained risk factor information from cases of invasive and in-situ breast cancer and from population controls through a telephone interview. At the end of the telephone interview, women were invited to participate in the buccal cell component of the study. Approximately 82 percent of eligible breast cancer cases and 78 percent of eligible controls agreed to participate in the study interview. A total of 7,833 subjects, representing approximately 75 percent of cases and 70 percent of controls that completed the interview, provided a cytobrush or mouthwash buccal cell sample. The main research projects being conducted include identification of genetic susceptibility loci for breast cancer, including evaluation of gene-gene interactions, and in combination with other risk factor information to evaluate gene-environment interactions. Investigators are also collecting mortality information from breast cancer cases in the study using the National Death Index to evaluate determinants of survival.
For more information, contact Montserrat García-Closas.