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Discovering the causes of cancer and the means of prevention

Oncogene Translocations and Non-Hodgkin Lymphoma (NHL)

DCEG investigators are examining the role of genomic instability in the etiology of NHL with HIV-infection as well as in the general population, using materials from cohort and case-control studies conducted by the Division. This project builds upon the  previous observation of the t(8;14) translocation in circulating lymphocytes from HIV-infected patients without NHL. Lymphoma specimens from the Prostate Lung Colorectal and Ovarian (PLCO) cancer screening trial have been tested for consenses translocation sequences of t(14;18) and t(11;14). Prediagnostic peripheral blood lymphocytes will be examined for oncogenic chromosomal translocations associated with risk of subsequent NHL and/or clonally related to these tumors. Lymphoma specimens will be examined for tumor suppressor gene and oncogene alterations, and viral DNA sequences. Nested case-control and cohort analyses will be used to determine risk factors for these abnormalities, and their association with risk of subsequent NHL.

For more information, contact Charles Rabkin.

Infections and Immunoepidemiology Branch – Research Areas