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Discovering the causes of cancer and the means of prevention
 

National Ovarian Cancer Prevention and Early Detection Study (GOG-0199) Related Study Publications

Primary Analyses of GOG-0199 Data

  • Greene MH, Piedmonte M, Alberts D, Gail M, Hensley M, Miner Z, Mai PL, Loud J, Rodriguez G, Basil J, Boggess J, Schwartz PE, Kelley JL, Wakeley KE, Minasian L, Skates S: A prospective study of risk-reducing salpingo-oophorectomy and longitudinal CA-125 screening among women at increased genetic risk of ovarian cancer: design and baseline characteristics: a Gynecologic Oncology Group study. Cancer Epidemiol Biomarkers Prev 2008; 17:594-604
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  • Skates SL, Mai PL, Horick NK, Piedmonte M, Drescher CW, Isaacs C, Armstrong DK, Buys SS, Rodriguez GC, Horowitz IR, Berchuck A, Daly MB, Domchek S, Cohn DE, Van Le L, Schorge JO, Newland W, Davidson SA, Barnes M, Brewster W, Azodi M, Nerenstone S, Kauff ND, Fabian CJ, Sluss PM, Nayfield SG, Kasten CH, Finkelstein DM, Greene MH, Lu K: Large prospective study of ovarian cancer screening in high-risk women: CA125 Cut-point defined by menopausal status. Cancer Prev Res 2011; 4(9):1401-1408

Consortium of Modifiers of BRCA1/2 (CIMBA) Collaboration

  • Antoniou AC, et al. Common variants in 8q24, LSP1 and 2q35 and breast cancer risk among BRCA1 and BRCA2 mutation carriers. Hum Mol Genet 2009; 18:4442-4456
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  • Osorio A, et al. Evaluation of a candidate breast cancer associated SNP in ERCC4 as a phenotypic modifier in BRCA1/2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA). Br J Cancer 2009; 101: 2048-2054
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  • Antoniou AC, et al. Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction. Cancer Res 2010; 70:9742-9754
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  • Antoniou AC, et al. A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nat Genet 2010; 42(10):885-892
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  • Gaudet MM, et al. Common genetic variants and modification of penetrance of BRCA2-Associated breast cancer. PLoS Genet 2010; 6(10), e1001183
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  • Jakubowska A, et al. The Leu33Pro polymorphism in the ITGB3 gene does not modify BRCA1/2-associated breast or ovarian cancer risks: results from a multicenter study among 15,542 BRCA1 and BRCA2 mutation carriers. Br Cancer Res Treat 2010; 121(3):639-49
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  • Im KM, et al. Haplotype structure in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriers. Hum Genet 2011; 130(5):685-699
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  • Antoniou AC, et al. Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers. Hum Mol Genet 2011; 20(16):3304-3321
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  • Cox DG, et al. Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers. Hum Mol Genet 2011; 20(23):4732-4747
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  • Ramus SJ, Antoniou AC, et al.: Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 carriers. Hum Mutat 2012; 33(4):690-702
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  • Couch F, Gaudet MM, et al. Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev 2012; 21(4):645-657
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  • Stevens KN, Wang X, et al.: Evaluation of chromosome 6p22 as a breast cancer risk modifier locus in a follow-up study of BRCA2 mutation carriers. Breast Ca Res Treat 2012; 136(1):395-302
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  • Antoniou AC, et al. Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. Breast Cancer Research 2012; 14(1):R33, [Epub in advance of print]
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  • Ding YC, Neuhausen S, et al.  A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev 2012; 21(8):1362-1370