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Discovering the causes of cancer and the means of prevention

EBV and Genetics in AIDS NHL

DCEG investigators seek to clarify the roles of Epstein-Barr virus (EBV) and common variants in genes controlling immunity and inflammation on the risk of AIDS-related non-Hodgkin lymphoma. In collaboration with the Multicenter AIDS Cohort Study, the interactions of EBV load, EBV cellular and humoral immunity, and variants in candidate genes are being studied in 181 incident lymphomas and matched controls. To identify novel genetic associations, investigators plan to genotype 800 additional cases assembled from several sources with a haplotype-tagging panel of more than 150 genes on pathways implicated in lymphomagenesis.

For more information, contact Eric Engels.

Infections and Immunoepidemiology Branch – Research Areas