Although second primary cancers are a leading cause of death among men with testicular cancer, few studies have quantified risks among long-term survivors. Radiation Epidemiology Branch investigators and collaborators conducted an international study of 14 population-based tumor registries. They identified 40,576 1-year survivors of testicular cancer and ascertained data on new incident solid tumors. Among 10-year survivors diagnosed with testicular cancer at age 35 years, the risk of developing a second solid tumor was increased (RR = 1.9). Risk remained statistically significantly elevated for 35 years, and for the first time, significantly elevated risks were observed for cancers of the pleura (malignant mesothelioma), and esophagus.
Men diagnosed with testicular cancer before age 55 years had a low cumulative risk (1.9% at 15 years) of a metachronous contralateral testicular cancer and favorable overall survival, which supported the current U.S. approach of not performing a biopsy on the contralateral testis.
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