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Discovering the causes of cancer and the means of prevention

Transplant-Associated Malignancies

Cancer risk is substantially elevated among solid organ transplant recipients, who receive long-term immunosuppressant medications to prevent organ rejection. To better understand the etiology of cancer in this population, investigators are conducting the Transplant Cancer Match Study. This study is a collaborative effort with the Health Resources and Services Administration, which oversees the U.S. solid organ transplant network. Data from multiple state and regional cancer registries are linked with the U.S. registry of transplant recipients, to cover more than 50% of the U.S. transplant population. 

Goals of the project include: 1) description of the spectrum of cancer risk in solid organ transplant recipients; 2) elucidation of the role of oncogenic viruses in causing cancer in this setting; and 3) understanding the role of other factors in causing cancer, such as demographic factors, medical conditions, and specific immunosuppressive medication.

For more information, contact Eric Engels.

Infections and Immunoepidemiology Branch – Research Areas

Transplant Cancer Match Study Website