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Discovering the causes of cancer and the means of prevention

Radiation Exposures among Mayak Nuclear Facility Workers

DCEG investigators have been collaborating with Russian colleagues to study the effects of protracted exposure to external radiation at relatively high doses and of exposure to plutonium in a cohort of 26,000 Mayak nuclear facility workers (in the Russian Federation). Using recently improved dose estimates, dose-response relationships for exposure to plutonium were demonstrated for mortality from cancers of the lung, liver, and bone, the three major sites of plutonium deposition. Dose-response relationships for exposure to external radiation were demonstrated for mortality from leukemia, lung cancer, and for the category all solid cancers other than lung, liver, and bone. Further analyses of other site-specific cancers are underway.

For more information, contact Ethel Gilbert.

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