The PLCO Atlas, GWAS Explorer
The PLCO Atlas is an interactive tool that enables researchers to search for, visualize, and download aggregated association results from the PLCO genome-wide association analyses (GWAS).
The resource includes genotype data of 110,562 PLCO subjects (on 5 different Illumina arrays and the imputed data against the TopMed reference panel 5b through the Michigan Imputation Server) as well as a comprehensive list of over 200 phenotypes collected from questionnaire data, linkage to medical records, cancer registries, and the National Death Index.
Tools are available to visualize association results by interactive Manhattan plots that allow for stratification by sex as well as other diagnostic plots (e.g., Q-q plots) and resources to compare genetic correlations across phenotypes. Furthermore, descriptive characteristics of PLCO, annotation of phenotypes, and links to other pertinent genomic resources are available.
The Prostate, Lung, Colorectal, Ovarian (PLCO) Cancer Screening Study is a large population-based randomized trial designed and sponsored by the National Cancer Institute (NCI) to determine the effects of screening on cancer-related mortality and secondary endpoints in men and women aged 55 to 74. The screening component of the trial was completed in 2006.