The Division of Cancer Epidemiology and Genetics (DCEG) is a research program of the National Cancer Institute (NCI), one of the National Institutes of Health (NIH). The Division is the world’s most comprehensive cancer epidemiology research group. Its renowned epidemiologists, geneticists, and biostatisticians conduct population and multidisciplinary research to discover the genetic and environmental determinants of cancer and new approaches to cancer prevention. The Division’s research informs public health policy in the United States and around the world. To learn more, read our Mission Statement.
DCEG carries out its research program with a cadre of in-house researchers and trainees. Our investigators conduct research on most cancer organ sites among diverse populations in the United States and around the world. They utilize a full range of research approaches to study risk factors ranging from workplace exposures to lifestyle choices. For complete descriptions, see an explanation of our research.
DCEG research is conducted within two program areas and nine research branches:
The Epidemiology and Biostatistics Program (EBP) conducts independent and collaborative epidemiologic and biostatistical investigations.
The Biostatistics Branch (BB) develops statistical methods and data resources to support epidemiological studies of cancer, including genetic, descriptive and analytical epidemiology, cancer risk assessment modeling, and other collaborative studies.
Hormonal and Reproductive Epidemiology Branch
The Hormonal and Reproductive Epidemiology Branch (HREB) studies hormonally-related cancers and cancers of the reproductive system, including breast (both male and female), endometrium, ovary, cervix, prostate, and testis. HREB investigators also seek to understand the epidemiology of other hormonally-influenced malignancies, including cancers of bladder, liver, esophagus and stomach.
Infections and Immunoepidemiology Branch
The Infections and Immunoepidemiology Branch (IIB) investigates the role of infectious agents and host immunological and inflammatory responses in cancer etiology, using epidemiological and molecular tools within well-characterized population studies. IIB investigators seek to apply the knowledge they gain from these studies to prevention and/or improved risk prediction, diagnosis, or treatment efforts.
Nutritional Epidemiology Branch
The Nutritional Epidemiology Branch (NEB) studies the causal relations between nutrition, nutrition-related factors, and human cancer. Its research encompasses diet, energy balance and obesity, physical activity, specific nutrients and supplements, diet-related additives, contaminants, metabolites, and intermediate biologic markers.
Occupational and Environmental Epidemiology Branch
The Occupational and Environmental Epidemiology Branch (OEEB) conducts interdisciplinary research to identify occupational, environmental, and other factors affecting cancer risk, characterize exposure-response relationships, identify susceptible populations and gene-environment interactions, clarify biological mechanisms of action, evaluate risk factors for tumor subtypes defined at the histologic and molecular level, and improve research methods for occupational investigations.
Radiation Epidemiology Branch
The Radiation Epidemiology Branch (REB) carries out a broad-based research program designed to identify, understand, and quantify the risk of cancer in populations exposed to medical, occupational, or environmental radiation.
The Human Genetics Program conducts interdisciplinary research into the genetic determinants of human cancer, taking advantage of advances in molecular genetics and related biomedical sciences.
Clinical Genetics Branch
The Clinical Genetics Branch (CGB) conducts multidisciplinary research to advance our understanding of how cancer develops at the molecular level, and to translate this knowledge into effective clinical applications for cancer-prone individuals and families.
Genetic Epidemiology Branch
The Genetic Epidemiology Branch (GEB) designs and conducts interdisciplinary clinical, epidemiologic, genetic, and laboratory studies of persons, families, and populations at high risk of cancer. These investigations identify genes and exposures that cause cancer predisposition, and explore the combined effects of predisposition and specific exposures.
Laboratory of Translational Genomics
The Laboratory of Translational Genomics (LTG) is committed to understanding the contribution of germline genetic variation to cancer etiology and outcomes. LTG conducts focused studies to explain the functional significance of particular regions of the genome conclusively identified in cancer-specific genome-wide association studies (GWAS) and linkage studies in high-risk families.