Investigators in the Infections and Immunoepidemiology Branch (IIB) conduct multidisciplinary studies of carefully selected domestic and foreign populations, with the goal of clarifying the relationship of infectious agents, especially viruses, to human cancer and other conditions.
IIB’s research mission is to discover infectious causes of cancer, to elucidate the determinants of malignancy for established oncogenic infections, to uncover novel infection-cancer associations, and to clarify how alterations in immunity and inflammation relate to cancer risk.
IIB investigators collaborate with researchers from a variety of disciplines in the U.S. and abroad. In addition to epidemiologic and clinical data, many IIB field studies include an extensive biological specimen collection component that allows for careful molecular testing to better define both exposures and outcomes of interest
Learn more about specific IIB research areas.
Working closely with tenured and tenure-track investigators, IIB fellows take lead responsibility for analyzing and summarizing previously collected data. Senior staff assist them in writing manuscripts and bringing these to publication in the peer-reviewed scientific literature. Fellows become familiar with the entire IIB portfolio and are encouraged to participate in on-going and newly proposed studies within the Branch and throughout the Division. Meet the current IIB fellows and learn about research training opportunities in IIB.
Sam Mbulaiteye from IIB has recently been highlighted in the Black Bag NCI Special Report/Journal of Minority Medical Students. View his interview here.
Cell illustration credit: Kristy Whitehouse
Aka P, et al. Endemic Burkitt lymphoma is associated with strength and diversity of Plasmodium falciparum malaria stage-specific antigen antibody response.. Blood 2013;[Epub ahead of print]
Hildesheim P, et al. Invited Commentary: Epstein-Barr Virus-Based Screening for the Early Detection of Nasopharyngeal Carcinoma-A New Frontier. Am J Epidemiol 2013;177:251-3
Kreimer AR, et al. Evaluation of Human Papillomavirus Antibodies and Risk of Subsequent Head and Neck Cancer. J Clin Oncol 2013;[Epub ahead of print]
Prokunina-Olsson L, et al. A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus.. Nat Genet 2013;45:164-71
Gillison ML, et al. Prevalence of Oral HPV Infection in the United States,2009-2010. JAMA 2012;307:693-703
Shiels MS, et al.Impact of the HIV epidemic on the incidence rates of anal cancer in the United States. J Natl Cancer Inst 2012;104:1591-8
Camargo MC, et al. Divergent trends for gastric cancer incidence by anatomical subsite in US adults. Gut 2011;60:1644-9
Engels EA, et al. Spectrum of cancer risk among US solid organ transplant recipients. JAMA 2011;306:1891-901
Kreimer AR, et al. Proof-of-principle evaluation of the efficacy of fewer than three doses of a bivalent HPV16/18 vaccine. J Natl Cancer Inst 2011;103:1444-51