Investigators in the Infections and Immunoepidemiology Branch (IIB) conduct multidisciplinary studies of carefully selected domestic and foreign populations, with the goal of clarifying the relationship of infectious agents, especially viruses, to human cancer and other conditions.
IIB’s research mission is to discover infectious causes of cancer, to elucidate the determinants of malignancy for established oncogenic infections, to uncover novel infection-cancer associations, and to clarify how alterations in immunity and inflammation relate to cancer risk.
IIB investigators collaborate with researchers from a variety of disciplines in the U.S. and abroad. In addition to epidemiologic and clinical data, many IIB field studies include an extensive biological specimen collection component that allows for careful molecular testing to better define both exposures and outcomes of interest
Learn more about specific IIB research areas.
Working closely with tenured and tenure-track investigators, IIB fellows take lead responsibility for analyzing and summarizing previously collected data. Senior staff assist them in writing manuscripts and bringing these to publication in the peer-reviewed scientific literature. Fellows become familiar with the entire IIB portfolio and are encouraged to participate in on-going and newly proposed studies within the Branch and throughout the Division. Meet the current IIB fellows and learn about research training opportunities in IIB.
Tenure-track investigators Anil Chaturvedi, Jill Koshiol, and Aimee Kreimer explore infection, inflammation, and cancer.
Cell illustration credit: Kristy Whitehouse
Aka P, et al. Endemic Burkitt lymphoma is associated with strength and diversity of Plasmodium falciparum malaria stage-specific antigen antibody response. Blood 2013;122:629-635
Chaturvedi AK, et al. Worldwide trends in incidence rates for oral cavity and oropharyngeal cancers. J Clin Oncol 2013;31:4550-4559
Kreimer AR, et al. Evaluation of human papillomavirus antibodies and risk of subsequent head and neck cancer. J Clin Oncol 2013;31:2708-2715
Prokunina-Olsson L, et al. A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus. Nat Genet 2013;45:164-171
Safaeian M, et al. Durable antibody responses following one dose of the bivalent human papillomavirus L1 virus-like particle vaccine in the Costa Rica Vaccine Trial. Cancer Prev Res 2013;6:1242-1250
Cancer Genome Atlas Research Network. Comprehensive molecular characterization of gastric adenocarcinoma. Nature 2014;513:202-209
Chang CM, et al. GBV-C infection and risk of NHL among U.S. adults. Cancer Res 2014;74:5553-5560
Shiels MS, et al. Cigarette smoking and variations in systemic immune and inflammation markers. J Natl Cancer Inst 2014;1:106-111
Porras C, et al. Performance of self-collected cervical samples in screening for future precancer using human papillomavirus DNA testing. J Natl Cancer Inst 2014;107:400