The Metabolic Epidemiology Branch focuses on high-quality, high-impact research that seeks to understand the etiology of a number of malignancies and the role of various lifestyle factors and unique exposures. Our research is predicated on rigorous epidemiologic approaches, with integration of state-of-the-art methods for defining exposures of interest.
Studies focused on understanding the etiology of various cancers include:
Studies that seek to define the role of lifestyle and other exposures in cancer risk include:
MEB investigators are utilizing emerging methods and technologies to further their research, including:
Metabolomics – Investigators are testing associations between blood and urine metabolites and colon, pancreas, and breast cancers. This includes both agnostic assessments and evaluation of metabolomic biomarkers of exposures, such as diet, physical activity, and tobacco.
Microbiome – Investigators are conducting a colorectal cancer case-control analysis incorporating assessment of the fecal microbiome and fecal metabolomics. They are also carrying out a large, nested case-control study of the oral microbiome and cancer at multiple locations, including head and neck, esophagus, stomach, lung, pancreas, and colorectum. In addition, investigators are participating in the Microbiome Quality Control project.