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Clinical Genetics Branch

Saving lives and improving the quality of life for individuals at increased genetic risk of cancer

Clinical Genetics Branch (CGB) investigators conduct clinical, genetic, and epidemiologic studies of individuals at high genetic risk of cancer in order to improve our understanding of cancer etiology and to advance clinical care.

Research Mission

CGB's research mission is to conduct multidisciplinary research to advance our understanding of the molecular pathogenesis of cancer and to translate this knowledge into effective clinical applications for cancer-prone individuals and families. Learn about specific CGB research areas.


CGB fellows work with researchers engaged in conducting clinical research studies targeting high-risk families, in pursuing astute clinical observations of unusual cancer occurrences that might provide new clues to cancer etiology, and in applying epidemiologic methods to the study of high-risk individuals. Meet the current CGB fellows and learn about research training opportunities in CGB.

CGB Spotlight

Douglas Stewart, M.D., Tenure-track Investigator

Dr. Douglas Stewart joined CGB in 2010 as one of NIH's first Earl Stadtman Investigators, in recognition of his investigation into the classic monogenic tumor predisposition syndrome neurofibromatosis type 1 (NF1). Read more about Douglas Stewart.

CGB Highlights

Ballew BJ,...Giri N,...Alter BP, Savage SA. Germline mutations of regulator of telomere elongation helicase 1, RTEL1, in Dyskeratosis congenita. Hum Genet 2013 Jan 18 [Epub ahead of print]

Mirabello L,...Schiffman M, Wentzensen N, et al. Methylation of human papillomavirus type 16 genome and risk of cervical precancer in a Costa Rican population. J Natl Cancer Inst 2012;104:556-565 

Alter BP, Rosenberg PS … Savage SA. Telomere length is associated with disease severity and declines with age in dyskeratosis congenita.  Haematologica 2012; 97(3):353-9

Gadalla SM, Lund M … Greene MH. Cancer risk among patients with myotonic muscular dystrophy.  JAMA 2011; 306(22):2480-6

Mai PL, Malkin D … Greene MH, Fraumeni JF Jr, Savage SA. Li-Fraumeni syndrome: Report of a clinical research workshop and creation of a research consortium. Cancer Genetics 2012; 205(10):479-87

Mirabello L, Yu K … Savage SA.  A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma.  BMC Cancer 2011; 11(1):209

Schiffman M, Rodriguez AC, Chen Z, et al. A population-based prospective study of carcinogenic human papillomavirus variant lineages, viral persistence, and cervical neoplasia. Cancer Res 2010; 70(8):3159-69