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Discovering the causes of cancer and the means of prevention

Clinical Genetics Branch

Saving lives and improving the quality of life for individuals at increased genetic risk of cancer

Clinical Genetics Branch (CGB) investigators study individuals at high genetic risk of cancer in order to improve our understanding of cancer etiology and to advance clinical care. This work is carried out through two major research approaches: familial studies and clinical genetics. Read about some of our contributions to improving public health for these high-risk individuals.  

Research Mission

CGB's research mission is to conduct multidisciplinary research to advance our understanding of the molecular pathogenesis of cancer and to translate this knowledge into effective clinical applications for cancer-prone individuals and families. The clinical epidemiology unit focuses on absolute risk of cancer, with the ultimate goal of informing risk-based cancer screening and prevention guidelines. Learn about specific CGB research areas.


CGB fellows work with researchers engaged in conducting clinical research studies targeting high-risk families, in pursuing astute clinical observations of unusual cancer occurrences that might provide new clues to cancer etiology, and in applying epidemiologic methods to the study of high-risk individuals. Meet the current CGB fellows and learn about research training opportunities in CGB.

CGB Spotlight

Shahinaz Gadalla, M.D., Ph.D, Tenure-track Investigator

Dr. Gadalla joined CGB in 2008 to investigate the role of genetic factors in cancer etiology and to explore factors that may modify disease risk among individuals at high risk of developing cancer. She was recently appointed as an NIH Earl Stadtman Investigator. Read more about Dr. Gadalla's appointment.