The Cancer Genomics Research Laboratory (CGR) investigates the contribution of germline and somatic genetic variation to cancer susceptibility and outcomes in support of DCEG's research. Working in concert with epidemiologists, biostatisticians and basic research scientists in DCEG’s intramural research program, CGR provides the capacity to conduct genome-wide discovery studies and targeted regional approaches to identify the heritable determinants of various forms of cancer.
CGR’s high throughput laboratory is equipped with state-of-the-art laboratory equipment and automation systems for a large number of applications. CGR supports DCEG in all stages of cancer research from planning to publishing, including experimental design and project management, sample handling, genotyping and sequencing assay design and execution, development and implementation of bioinformatic pipelines, and downstream scientific research and analytical support.
Utilizing the newest technologies, CGR conducts scientific research in support of DCEG investigators via genomic and analytical resources across a variety of applications, including:
Berndt Sl, et al. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Nat Genet 2013 Aug;45(8):868-76.
Mirabello L, et al. Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multi-case Diamond-Blackfan anemia families. Blood 2014 May 14. pii: blood-2013-11-540278.
Shi J, et al. Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma. Nat Genet 2014 May;46(5):482-6.