Integrative Tumor Epidemiology Branch

Investigators in the Integrative Tumor Epidemiology Branch (ITEB) employ molecular pathology, somatic and germline genomics, and epidemiology to identify environmental and germline risk factors for cancer.

Research Mission

The mission of ITEB is to conduct large-scale, epidemiological research on cancer etiology and progression through integrative analyses of risk factors and tissue profiling to inform prevention and clinical strategies. Learn more about research in ITEB.

Fellowships

ITEB provides a dynamic and collaborative environment for fellows at the pre- and postdoctoral levels.

ITEB Highlights

Díaz-Gay, M and Zhang T et al. The mutagenic forces shaping the genomic landscape of lung cancer in never smokers. Nature. 2025.

Abubakar M et al. Unraveling the role of stromal disruption in aggressive breast cancer etiology and outcomes.  JNCI. 2025.

Liu A, et al. Population analyses of mosaic X chromosome loss identify genetic drivers and widespread signatures of cellular selection. Nature. 2024.

Vo JB et al. Long-term cardiovascular disease risk after anthracycline and trastuzumab treatments in U.S. breast cancer survivors. J Natl Cancer Inst. 2024

Mullooly M, et al. Temporal changes in mammographic breast density and breast cancer risk among women with benign breast disease. Breast Cancer Res. 2024.

Purdue MP, et al. Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions. Nat Genet. 2024.

Machiela M, et al. GWAS Explorer: An open-source tool to explore, visualize, and access GWAS summary statistics in the PLCO Atlas. Scientific Data. 2023.

Lee OW, et al. Targeted long-read sequencing of the Ewing sarcoma 6p25.1 susceptibility locus identifies germline-somatic interactions with EWSR1-FLI1 binding. Am J Hum Genet. 2023.

Zhang T, et al. Genomic and evolutionary classification of lung cancer in never smokers. Nat Genetics. 2021.