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Discovering the causes of cancer and the means of prevention

Laboratory of Translational Genomics

Understanding the contribution of germline genetic variation to cancer etiology and outcomes

The Laboratory of Translational Genomics (LTG) conducts focused studies on particular regions of the genome conclusively identified in cancer-specific genome-wide association studies (GWAS) and linkage studies in high-risk families.

Research Mission 

LTG's mission is to understand the contribution of germline genetic variation to cancer etiology and outcomes. Its primary goals are to investigate regions of genetic variation by:

  • Detecting cancer susceptibility alleles
  • Fine mapping of susceptibility alleles using sequence analysis and imputation from public databases
  • Prioritizing variants for follow-up studies through bioinformatic analysis of candidate variants
  • Deciphering the biological mechanisms underlying susceptibility alleles through laboratory investigation

Learn more about specific LTG research areas.


LTG accepts fellowship applications on an ongoing basis. Meet the current LTG fellows and learn about research training opportunities in LTG.


Essential to the mission of the Laboratory is a close collaboration with the NCI-Frederick Cancer Genomics Research Laboratory (CGR). Formerly known as the Core Genotyping Facility (CGF), this laboratory designs and conducts high throughput sequencing, genotyping, and analysis in support of large scale epidemiologic studies.

LTG in the News

Explore an assortment of talks, videos, and news items by LTG staff.

LTG Highlights

Ghosh A, Hartge P, Purdue MP, Chanock SJ, Amundadottir L, Wang Z, Wentzensen N, Chatterjee N, Wacholder S. Assessing Disease Risk in Genome-wide Association Studies Using Family History. Epidemiology 2012

Chung CC, Boland J, Yeager M, Jacobs KB, Zhang X, […] Chanock SJ. Comprehensive resequence analysis of a 123-kb region of chromosome 11q13 associated with prostate cancer. Prostate 2012

Postel-Vinay S, […] Chanock SJ, Thomas G, Cox DG, Delattre O. Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma. Nat Genet 2012

Li D, Duell EJ, Yu K, […] Amundadottir L*, Stolzenberg-Solomon RZ*. Pathway Analysis of Genome-wide Association Study Data Highlights Pancreatic Development Genes as Susceptibility Factors for Pancreatic Cancer. Carcinogenesis 2012       *co-last authors

Wang Z, Parikh H, Jia J, Myers T, Yeager M, […] Amundadottir L. Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry. Hum Genet 2012

Fu YP, Kohaar I, Rothman N, Earl J, Figueroa JD, […] Prokunina-Olsson L. Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk. Proc Natl Acad Sci USA 2012

Tang W, Fu YP, Figueroa JD, Malats N, Garcia-Closas M, […] Prokunina-Olsson L. Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancer. Hum Mol Genet 2012

Stark MS, Woods SL, Gartside MG, Bonazzi VF, Dutton-Regester K, […] Brown KM, Gibbs R, Trent J, Hayward NK. Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. Nat Genet 2011