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Discovering the causes of cancer and the means of prevention

Clinical Genetics Opportunities with Specific Investigators

Integrating Genomic and Epidemiological Data in Understanding Disease Outcome
Dysregulation of miRNA in Rare and Common Malignancies
Inherited Bone Marrow Failure Syndromes of Childhood

Integrating Genomic and Epidemiological Data in Understanding Disease Outcome - Postdoctoral Fellowship

Cancer Risk in Myotonic Dystrophy: Investigators at the Clinical Genetics Branch were the first to report epidemiological evidence of excess cancer risk in patients with the neuromuscular disorder, myotonic dystrophy (DM). This work identified DM as a new cancer susceptibility syndrome. Our current research aims at understanding the cancer risk factors and the molecular mechanisms behind this observation.

Predictors of Outcomes After Hematopoietic Cell Transplantation (HCT):  Our work in this area has identified donor telomere length as an important predictor for patient survival after HCT for severe aplastic anemia. We are expanding our work to include other diseases and to identify novel genomic predictors associated with patient outcome after HCT.

Qualifications:  Applicants with a doctoral degree in genetics/genomics, epidemiology, or related field are encouraged to apply. Experience in analyses of large-scale genomic sequence data is a plus. A successful candidate will work with highly committed and talented researchers with expertise in epidemiology, biostatistics, and genomics, and will have extensive career development training opportunities through the DCEG Office of Education. Salary and benefits are highly competitive and commensurate with experience.

For More Information: contact Shahinaz Gadalla, M.D., Ph.D.

See the Division Fellowship Information page for general overview, qualifications, and application details.

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Dysregulation of miRNA in Rare and Common Malignancies - Postdoctoral Fellowship

Cancer Risk in the DICER1 Syndrome, the First Recognized miRNAopathy: Germline variants in DICER1, a critical gene involved with microRNA biogenesis, are associated with a variety of rare and common malignancies, including pleuropulmonary blastoma (PPB), Sertoli-Leydig cell tumors, Wilms tumor and thyroid cancer. In collaboration with the International PPB Registry, we are comprehensively evaluating individuals with pathogenic germline DICER1 variants. Current and planned work in this population combines detailed clinical phenotyping, epidemiologic and biostatical analyses, population-based whole-exome and whole-genome sequencing, and miRNA profiling to quantify cancer risk and elucidate cancer pathogenesis. Our primary goal is to develop effective methods for identifying DICER1 mutation carriers and DICER1-associated tumors.

A successful candidate will work with deeply committed and talented researchers with expertise in epidemiology, oncology, clinical genetics, biostatistics, and genomics. Fellows in DCEG have extensive career development and training opportunities through the Clinical Genetics Branch and the division’s Office of Education. Salary and benefits are highly competitive and commensurate with experience.

Qualifications:  Applicants with a doctoral degree (M.D. or Ph.D.) in genetics/genomics, oncology, epidemiology, or related fields are encouraged to apply. Experience with analyses of large-scale genomic sequence data is highly desired.

For More Information: contact Douglas R. Stewart, M.D.

See the Division Fellowship Information page for general overview, qualifications, and application details.

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Training in the Inherited Bone Marrow Failure Syndromes of Childhood

CGB is seeking a clinically-trained pediatric or medical hematology/oncology physician with research interests in the Inherited Bone Marrow Failure disorders, e.g., Fanconi anemia, dyskeratosis congenita, Diamond Blackfan anemia, Shwachman Diamond syndrome, Thrombocytopenia Absent Radii syndrome, etc., who desires a postdoctoral research opportunity which is focused on these rare conditions.

The Branch is now more than 12 years into assembling and analyzing the world's largest cohort of affected families, systematically collecting demographic, medical, epidemiologic, genetic, and psychosocial/behavioral data plus carefully-annotated biospecimens, to support etiologically-oriented translational research. This includes the opportunity to learn the clinical phenotype of these diseases first-hand, participate in the evaluation of clinical research protocol participants, become involved in the analysis and publication of data derived from this cohort, and acquire new skills related to clinical genetics and epidemiology.

Qualifications: Individuals with clinical training in pediatric or medical hematology/oncology who also have a strong interest in inherited bone marrow failure and cancer predisposition syndromes are sought for this position. Previous training or experience in genetics, epidemiology, and/or biostatistics would be highly beneficial, although not required.

For further information, please contact either Dr. Blanche Alter or Dr. Sharon Savage.

See the Division Fellowship Information page for general overview, qualifications, and application details.

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