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Discovering the causes of cancer and the means of prevention

Laboratory of Translational Genomics Opportunities with Specific Investigators

Investigating genetic variants underlying pancreatic cancer risk

A postdoctoral position is available within the Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute within the laboratory of Dr. Laufey Amundadottir.

The main interest of our laboratory focuses on inherited predisposition to pancreatic cancer and functional characterization of common and infrequent risk variants identified by genome-wide association studies (GWAS) and sequence based approaches. We conduct and lead such studies, termed PanScan, within the Cohort Consortium of the National Cancer Institute, NIH, in collaboration with research groups worldwide.

Specifically, this opening is for a highly motivated individual interested in functional and translational laboratory investigations to identify target genes and understand the functional consequences of carrying pancreatic cancer risk variants. We use targeted molecular biology approaches in small genomic regions surrounding the most significant risk variants as well as high-throughput genome-wide genomic approaches (RNA-seq, ChIP-seq etc.) to identify functional risk variants and understand their role in mediating cancer risk. We seek to correlate risk genotypes to molecular phenotypes that include regulatory potential, transcription factor binding, chromatin interaction, epigenetics and regulation of gene expression in cis and in trans.


Candidates should have a Ph.D. in molecular biology, cell biology or biochemistry and no more than five years of post-doctoral experience. We seek self-motivated individuals who have an excellent understanding of molecular and cellular biology and experience in the analysis of gene expression, transcriptional control, gene regulatory elements, protein function, signal transduction and growth control. An understanding of genetics and genomics is a plus as well as a strong publication record and effective written and verbal communication skills.

For more details on the opportunity, please contact Dr. Amundadottir.

See the Division Fellowship Information page for a general overview, qualifications, and application details.