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Discovering the causes of cancer and the means of prevention

Laboratory of Translational Genomics Opportunities with Specific Investigators

Investigating Genetic Variants Underlying Pancreatic Cancer Risk
Investigating Epigenetic Mechanisms In Urologic Cancers
Investigating Genetic Variants Underlying Risk of Melanoma and Renal Cell Cancer

Investigating Genetic Variants Underlying Pancreatic Cancer Risk

A postdoctoral position is available in the Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, within the laboratory of Dr. Laufey Amundadottir.

The main interest of our laboratory focuses on inherited predisposition to pancreatic cancer and functional characterization of common and infrequent risk variants identified by genome-wide association studies (GWAS) and sequence-based approaches. We conduct and lead such studies, termed PanScan, within the Cohort Consortium of the National Cancer Institute, NIH, in collaboration with research groups worldwide.

Specifically, this opening is for a highly motivated individual interested in functional and translational laboratory investigations to identify target genes and understand the functional consequences of carrying pancreatic cancer risk variants. We use targeted molecular biology approaches in small genomic regions surrounding the most significant risk variants as well as high-throughput genome-wide genomic approaches (RNA-seq, ChIP-seq etc.) to identify functional risk variants and understand their role in mediating cancer risk. We seek to correlate risk genotypes to molecular phenotypes that include regulatory potential, transcription factor binding, chromatin interaction, epigenetics and regulation of gene expression in cis and in trans.

Qualifications

Candidates should have a Ph.D. in molecular biology, cell biology or biochemistry and no more than five years of postdoctoral experience. We seek self-motivated individuals who have an excellent understanding of molecular and cellular biology and experience in the analysis of gene expression, transcriptional control and gene regulation, protein function, signal transduction and growth control. An understanding of genetics and genomics is a plus as well as a strong publication record and effective written and verbal communication skills.

For more details on the opportunity, please contact Dr. Amundadottir.

See the Division Fellowship Information page for a general overview, qualifications, and application details.

Investigating Epigenetic Mechanisms In Urologic Cancers

A postdoctoral position is available within the Laboratory of Translational Genomics (LTG),  Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute to work with staff scientist, Michael L. Nickerson, Ph.D. and LTG Chief, Michael Dean, Ph.D.

The focus of our work in the LTG is to identify cancer genes that are frequently altered in urologic cancers (bladder, prostate, and kidney) using next-generation sequencing of tumor genomes, PCR, and Sanger sequencing of candidate genes. We have identified a number of new frequently altered cancer genes that: correlate with clinically-relevant aspects of disease; alter the epigenetic functions conserved in healthy genomes; and identify patients with lethal disease. These genes will be developed as new biomarkers of disease progression and therapeutic intervention. We are now planning follow-up studies of gene-gene relationships, protein function, signaling pathways, and the effects of cancer-related alterations on the tumor epigenome.

This opening is for an individual interested in using molecular biology and high-throughput genome-wide genomic approaches (RNA-seq, ChIP-seq, etc.) to identify cancer gene product functions with roles in healthy tissues and in cancer initiation and development. The fellow will undertake studies: of cancer gene function in health and disease; on the effects of gene alterations on epigenetic modifications and their distribution: of genome processes such as mRNA expression; and on cancer cell behavior. The fellow will work with committed and talented researchers, with complementary areas of expertise, to produce high impact publications. Extensive career development opportunities are available through the DCEG Office of Education. Salary and benefits are highly competitive and commensurate with experience.

Qualifications

Candidates should have a Ph.D. in molecular biology, biochemistry, cell biology or epigenetics. We seek a self-motivated individual who has an excellent understanding of molecular and cellular biology, and demonstrated experience in the analysis of protein function, signal transduction, cell-based assays, or gene expression. An understanding of genetics and genomics, and experience with genome databases and statistical analysis are preferred, as well as a dedicated focus on publishing, and effective written and verbal communication skills. The candidate should possess excellent interpersonal and organizational skills, and the ability to collaborate on a multidisciplinary team.

For more information contact: Dr. Mike Nickerson

See the Division Fellowship Information page for a general overview, qualifications, and application details.

Investigating Genetic Variants Underlying Risk of Melanoma and Renal Cell Cancer

A postdoctoral position is available in the Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, within the laboratory of Kevin Brown, Ph.D.

The main interest of our laboratory focuses on inherited predisposition to melanoma and renal cell cancer, and functional characterization of common and infrequent risk variants identified by genome-wide association studies (GWAS) and sequencing-based approaches. We are members of the International Melanoma Genetics Consortium (GenoMEL) and collaborate in the areas of GWAS and family-based studies of melanoma risk, as well as lead ongoing melanoma and renal cell cancer GWAS efforts at the National Cancer Institute.

Specifically, this opening is for a highly motivated individual interested in functional and translational laboratory investigations to identify target genes and understand the functional consequences of carrying melanoma and or renal cancer risk variants. We apply both targeted and genome-wide (e.g. RNA sequencing, ChIP sequencing, methylation arrays) genetic and epigenetic methods to evaluate potential functional risk variants within associated chromosomal regions. We also apply cell biological methods to evaluate the phenotypic consequences of altered regulation of susceptibility genes on phenotypes associated with cancer progression.

Qualifications

Candidates should have a Ph.D. in molecular biology, genetics, cell biology, or biochemistry and no more than five years of postdoctoral experience. We seek self-motivated individuals who have an excellent understanding of molecular and cellular biology and experience in the analysis of gene expression, transcriptional control, gene regulatory elements, protein function, signal transduction and growth control. Aptitude for genomic data analysis and an understanding of genetics and genomics is a plus, as well as a strong publication record and effective written and verbal communication skills.

For more information, contact Dr. Brown.

See the Division Fellowship Information page for a general overview, qualifications, and application details.

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