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Laboratory of Translational Genomics Opportunities with Specific Investigators

Genetics and Genomics of Cancer

A postdoctoral position is available in the Amundadottir group within the Laboratory of Translational Genomics (LTG), Division of Cancer Epidemiology and Genetics, National Cancer Institute, for a highly motivated individual with a strong background in statistical genetics and genomics. The laboratory focuses on genome wide association studies (GWAS) of pancreatic cancer, and the investigation of the molecular basis of germline susceptibility alleles. A successful candidate will work on datasets that include GWAS data, and next generation sequence data for analysis of the transcriptome (RNA-Seq) and epigenome (Chip-Seq, MeDIP-ChIP), as well as Whole Genome Sequence of tumor/normal pairs and high risk families. Related projects in the laboratory include the investigation of: 1. the genetic factors associated with risk factors for pancreatic cancer, including BMI, diabetes and tobacco use; and 2. pleiotropy of common susceptibility alleles in which multiple cancers have mapped GWAS signals (e.g., 5p15.33, 8q24.21).

Qualifications

A doctoral degree in statistical genetics, bioinformatics or a related field is required and no more than 5 years of postdoctoral work. A strong background in cancer biology and experience in population research and/or analysis of large datasets is highly desirable. We are looking for applicants with programming skills (such as with R, SAS, STATA, Perl, or Python), experience in GWAS methods, imputation and analysis of next generation sequencing datasets.

Salary will be commensurate with research experience and is highly competitive.

To Apply

Submit a cover letter highlighting key qualifications and interests, a current CV and 3 letters of reference to:

Laufey Amundadottir, Ph.D
Laboratory of Translational Genomics
Division of Cancer Epidemiology and Genetics
National Cancer Institute
Advanced Technology Center
8717 Grovemont Circle
US Postal Address:
Bethesda, MD 20892-4605
E-mail: amundadottirl@mail.nih.gov

See the Division Fellowship Information page for an overview, qualifications, and application details.

Investigating the Biological Basis of Common Germline Risk Variants Identified Through Genome-Wide Association Studies

Dr. Laufey Amundadottir is looking for a postdoctoral fellow with a strong background in molecular biology, genomics and genetics. Candidates interested in functional and translational laboratory work to enhance our understanding of the functional underpinnings of risk variants identified by genome-wide association studies (GWAS) in cancer are encouraged to apply. Our laboratory uses high-throughput genome-wide approaches as well as targeted approaches in small genomic regions surrounding the most significant risk variants to understand the role common germline variants play in cancer risk. A successful candidate will work on projects that involve various molecular and cellular biology approaches such as the analysis of gene expression, splicing and regulation thereof, protein function, protein-protein interaction, genomics and genetics as well as whole genome sequencing approaches (RNA-seq, ChIP-seq and Whole Genome Sequencing). The major focus of our group is to investigate molecular phenotypes of association findings and provide an understanding of the genetic and biological basis of common germline risk variants for pancreatic cancer. For more details on the opportunity, please contact Dr. Amundadottir.

Qualifications

A doctoral degree in molecular or cellular biology, genetics or a related field is required. A strong background in genomics and the analysis of regulation of gene expression as well as bioinformatical/statistical methods to analyze complex data sets is a major advantage.

See the Division Fellowship Information page for an overview, qualifications, and application details.